Male mice lack nipples because the mammary tissue regresses in males during embryonic development. The single pair of mammary glands in humans is situated within the superficial facia of the anterior thoracic wall above the pectoralis major and extending upwards into the axilla. However, supernumerary...
Treatment with both genistein and methoxychlor altered gene expression profiles of the mammary glands in male rats, and the effects were more prominent in the combination treatment than the single-compound groups. Specific gene changes suggested that treatments affected the stromal and epithelial ...
This study investigates mammary tumors arising in 6 male mice from the A strain treated with keto-estrin benzoate given weekly by injection beginning at 28 days of age and for periods of from 101 to 199 days. Female mice of the same strain developed spontaneous mammary cancer in 80% of case...
A. (1996) New insights in the molecular mechanism of progestin‐induced proliferation of mammary epithelium: induction of the local biosynthesis of growth hormone (GH) in the mammary glands of dogs, cats and humans. J Steroid Biochem Mol Biol 57:67–71. 23. Schafer, K.A., Kelly, G.,...
Mammary glands are milk-producing glands found in mammals. In humans, mammary glands remain fairly undeveloped until a person...
Interestingly, glutaminase activity is absent from the lactating mammary glands; therefore, MEC maximize the production and release of glutamine [69]. The de novo synthesis of glutamate and glutamine helps to explain the high abundance of these two AA in both free and peptide-bound forms in milk...
How cancer patterns in humans compare to those of other species remains largely unknown and there is an even bigger knowledge gap for rare cancers like male breast cancer. One Health is a convergence of human and animal healthcare that encourages cross-pollination of medical research uniting human...
EXPERIMENTAL DESIGN: In order to assess whether antigenic similarities do occur between human and canine breast cancer, in the present study we have evaluated the immunohistochemical reactivity of two normal mammary glands and 62 benign and malignant canine breast tumors with a panel of six MoAbs, ...
in dogs or primates, and is more similar to the lobular development in the human breast than the simple branched structure of the adult mouse. During pregnancy and lactation, extensive growth and alveolar maturation occurs to form milk-producing glands. With growth of the gland, there is a ...
In their structure and mode of development, the mammary glands somewhat resemble the sweat glands.9During embryonic life, their differentiation is similar in the two sexes. Male humans experience little additional development postnatally. Female humans, in contrast, experience extensive structural change...