However, there are few studies regarding these markers in veterinary clinical oncology. Objectives To determine the serum concentrations of cancer antigen 15.3 ( CA 15.3), carcinoembryonic antigen ( CEA), and lactate dehydrogenase ( LDH) in female dogs with different ...
in tumor tissue) and can give information about the presence of a disease, results of treatment or further prognosis for the patient [17,18]. Every cancer cell expresses specific proteins that are called tumor-associated antigens. In patients with tumors, these antigens are called biomarkers ...
Bresciani, F.: Ovarian steroid control of cell proliferation in the mammary gland and cancer. In: Basic actions of sex steroids on target organs. Hubinont, P.O., Leroy, F., Galand, P. (eds.), pp. 130–159. Basel: Karger 1971 Google Scholar Brinkley, H.J., Wilfinger, W.W., ...
Fig. 2.Factors influencing pubertal mammary gland development. The tightly regulated window of pubertal mammary gland development has shown to be a key window of “cancer susceptibility” specific when looking at lifestyle factors, such as diet and obesity. Diets such as; a diet high in fat, ...
In the female dog, the utility of identification of CIS remains to be established, although known similarities with breast cancer disease in women would make it worthwhile to investigate. The lack of invasion of neighbouring tissues has been analysed through the assessment of both the integrity of...
IL-8 expression is inversely correlated with ER status, but positively correlated with estradiol; moreover, breast cancer patients with high levels of IL-8 during the early stages are in relation to shorter relapse-free survival (RFS), whereas patients with low IL-8 levels are associated with ...
30. The changes in the collagen structural architecture have been used also to successfully detect malignancies in the canine mammary gland31. In addition, collagen plays a significant role in the emergence of metastases, with a large amount of studies of cancer prognosis and therapies32,33,34,...
However, in cases with advanced stages and poor prognosis, α1AG levels remained higher on the 14th day. These results suggest that the α1AG concentration in dogs may be an indicator of the stage of mammary tumor, the possibility of recurrence and poor prognosis. 展开 关键词: α1-acid ...
Mammary ductal development in male humans does not differ from that in female humans until puberty. Even then, a rudimentary ductal system remains, which is why men can developgynecomastiaor breast cancer in later life. Thepostnatal developmentof female mammarygland tissueis also highly responsive to...
Canine mammary tumor is the most common neoplasm in female dogs, and it has generated considerable attention as a translational model for human breast cancer. Ser/Thr protein phosphatase 2A (PP2A) plays a critical role as a tumor suppressor, and SET/I2PP2A, the endogenous inhibitory protein of...