Mammary cancer in dogs is different to that in cats,. In dogs less than 50% mammary tumors are malignant and well over half of these can be cured with "conservative" surgery. Poor prognostic signs include large volume (> 3 cm diameter), recent rapidgrowth, ulceration and high histologic ...
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This chapter deals with canine mammary cancer and feline mammary cancer. It discusses the etiology/pathophysiology, epidemiology, signalment, history and clinical signs, diagnosis, therapy, and prognosis of the diseases. In female dogs, estrogens and progestins stimulate growth and development of ...
Mammary gland tumors are the third most common cancer in cats after skin tumors and lymphosarcoma. Although most feline mammary gland tumors are malignant, early detection, aggressive surgical therapy, and frequent postsurgical follow-up examinations have a significant effect upon prolonged survival time...
In the female dog, the utility of identification of CIS remains to be established, although known similarities with breast cancer disease in women would make it worthwhile to investigate. The lack of invasion of neighbouring tissues has been analysed through the assessment of both the integrity of...
Progestins and breast cancer. Progesterone (P) regulates proliferation and differentiation in the normal mammary gland in mouse, rat and human. Progesterone has also been implicated in ... M Aupperlee,A Kariagina,J Osuch,... - 《Breast Disease》 被引量: 113发表: 2005年 Evaluation of hormone...
(2009) Animal tumour registry of two provinces in northern Italy: incidence of spontaneous tumours in dogs and cats. BMC Vet Res 5:39. 7. Schneider, R. (1970) Comparison of age, sex, and incidence rates in human and canine breast cancer. Cancer 26:419–426. 8. Goldschmidt, M., ...
Feline mammary carcinoma (FMC) is the third most common type of neoplasia in cats, sharing similar epidemiological features with human breast cancer. In humans, histone deacetylases (HDACs) play an important role in the regulation of gene expression, with HDAC inhibitors (HDACis) disrupting gene ...
Cytokines such as IL-6, IL-8 and IL-10 are produced and secreted by activated immune cells such as macrophages, monocytes and lymphocytes, as well as by many cancer cell types10,11. These cytokines act in an autocrine or paracrine manner and promote cancer cell infiltration, metastasis and ...
less resistant to MMTV infection and produce MMTV particles in milk, which leads to the development of breast cancer in offspring [14]. The effects of MMTV in 129/SvEv are largely unknown; substrains are frequently used for breeding due to the availability of embryonal stem cells, and in ...