Male contraception, Androgens, Progestins, Spermatogenesis suppression, Contraceptive efficacyHormonal male contraception clinical trials began in the 1970s. The method is based on the use of exogenous testosterone alone or in combination with a progestin to suppress the endogenous production of ...
Historically, there hasn't been much interest from pharmaceutical companies in a male contraceptive. Running clinical trials takes years and is hugely expensive, so it's a risky endeavor when lots of options for female contraception already exist. A contraceptive gel for men is about to go on ...
Small clinical trials in India have shown that this procedure renders males temporarily azoospermic and prevents pregnancy for a year following the RISUG injection into both vas deferens.4Despite this, there has been little research conducted concerning the long-term effects of this contraceptive meth...
However, unless there are any life-threatening disadvantages that might occur like in the 1990 World Health Organization trials for male contraceptives, there are still valid reasons for developing male contraceptives as females are not exempt from contraceptive side effects either. Disadvantages of oral...
(2006). “A male contraceptive targeting germ cell adhesion” Nature Medicine 12(11): 1323-1328. Nieschlag, E. (2010). “Clinical trials in male hormonal contraception” Contraception 82(5): 457-470. Nieschlag, E. (2013). “Hormonal male contraception: end of a dream or start of a ...
RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook (redirected frommale sex hormones) Also found in:Dictionary,Thesaurus,Medical,Encyclopedia. MALE. Of the masculine sex; of the sex that begets young; the sex opposed to the female. Vide Gender; Man; Sex; Worth...
Current studies supported by the Contraceptive Discovery and Development Branch, NICHD, through the male Contraceptive Clinical Trials Network centers are studying new androgens with progestational activity (dimethandrolone), new progestins with...
The world population continues to increase dramatically despite the existence of contraceptive technology. The use of male hormonal contraception may help ... MY Roth,JK Amory - 《Clinical Pharmacology & Therapeutics》 被引量: 20发表: 2011年 Trial of Gossypol as a Male Contraceptive Male Contracepti...
(reviewed in30,45,46,47,48). For women, all pharmacologic strategies depend upon hormonal agents, which require continuous treatment to achieve contraceptive efficacy. Similarly, hormonal strategies for men currently in clinical trials work by blocking testicular sperm production. These methods49, as ...
Fig. 1: Proof-of-concept efficacy testing of male contraceptive effects of triptonide in mice. aRepresentative histology of the testis, epididymis, and sperm from mice that received vehicle (control) and triptonide (treated) at single daily oral doses of 0.8 mg/kg BW for 4 weeks, and...