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The presence of stable upsA var transcripts overcomes monoallelic expression, resulting in the simultaneous expression of both upsA and upsC type PfEMP1 proteins on the surface of individual infected red blood cells. In addition, we observe an inverse relationship between transcript levels of PfRNase...
Although upsB and upsC sub-groups overlapped, the upsA sub-group could be distinguished from others. Meanwhile, var4 and var84 had no upstream sequences but were assumed to be a sub-type of upsA as they were also within the upsA sub-group. Full size image Figure 2 Schematic diagram of...
var genes controlled by upsC are exclusively found toward the center of the chromosomes (Gardner et al., 2002, Voss et al., 2000). upsE is unique and regulates the var2CSA gene (PFL0030c; Gardner et al., 2002). We found that the var2CSA gene promoter upsE was immunoprecipitated by ...
derepressed in mutant P Sir2 parasites pointing to a distinct mechanism controlling silencing o upsB- and upsC-type var genes. Recently, a second P Sir2-related telomeric protein was discovered that controls repression o upsB-type var genes (Alan Cowman, personal communication). 5′ anking ...
The presence of stable upsA var transcripts overcomes monoallelic expression, resulting in the simultaneous expression of both upsA and upsC type PfEMP1 proteins on the surface of individual infected red blood cells. In addition, we observe an inverse relationship between transcript levels of PfRNase...