This has since also been found in Lao PDR, Vietnam, Thailand and Myanmar [7,8,9]. More recently, treatment failure to ACTs was found in Cambodia with resistance to both artemisinins and ACT partner drugs [10]. This has led to the rapid mobilisation of researchers and public health ...
Malaria infection in pregnant women can be more severe than in nonpregnant women. Malaria can increase the risk for adverse pregnancy outcomes, including prematurity, abortion, and stillbirth. For these reasons, and because no chemoprophylactic regimen is completely effective, women who are pregnant o...
It undoubtedly helps that South-east Asia does not have much malaria. In West Africa, where transmission is high, a child might be infected with three to five P. falciparum strains at any time, giving them many opportunities to mate and shuffle their genes. A Cambodian child, however, usual...
Resistance to artemisinin derivatives has mainly been reported in Southeast Asia (border between Thailand and Cambodia, border between Thailand and Myanmar, some regions of Laos, Vietnam, and the Yunnan province in China) [54]. This “resistance”—characterized by a longer time to parasite clearan...
This strategy worked in some Asian countries, including China, Vietnam, and Thailand, and in South America, particularly Brazil [48]. However, it did not have the desired effect in many countries with historically high levels of transmission. Moreover, the emergence of drug resistance in P. ...
falciparum was first observed in Cambodia in 2008 and subsequently reported in different neighbouring countries including Laos, Myanmar, Vietnam and Thailand [51, 52]. Later on, the mutation in the kelch 13 propeller gene which was associated with this resistance, was found spread in multiple ...
Genetic data is also helping us identify insecticide-resistant mosquitoes and drug-resistant forms of the disease. In Vietnam, health officials recently noticed an alarming spike of cases in one region of the country. Then genetic analysis of the parasite in that region revealed that they were fi...
This TPP was developed in an inclusive manner with field-based clinical experts, researchers, and drug developers. The overarching objective of the TPP is to propose a road map to guide and boost the development of a future generation of chemopreventive options. Current limitations of ...
In search of the last malaria cases: ethnographic methods for community and private-sector engagement in malaria elimination in Vietnam, Laos, and Cambodia. Malar J. 2021;20:370. Article PubMed PubMed Central Google Scholar Breeveld FJ, Vreden SG, Grobusch MP. History of malaria research ...
antimalarial drugs. Currently, this is even more alarming due to early reports ofP. falciparumresistance to ACTs (manifested as delayed clearance of parasitemia after treatment) in countries in the Greater Mekong subregion (Cambodia, Laos, Myanmar, Thailand and Vietnam) (Sibley, 2013;WHO,...