Malaria in pregnancy in India: a 50-year bird’s eye. Front Public Health. 2023;11:1150466. Article PubMed PubMed Central Google Scholar Nguee SYT, Júnior JWBD, Epiphanio S, Rénia L, Claser C. Experimental models to study the pathogenesis of malaria-associated acute respiratory ...
et al. Evidence for the involvement of VAR2CSA in pregnancy-associated malaria. J Exp Med 200, 1197–1203, 10.1084/jem.20041579 (2004). Article CAS PubMed PubMed Central Google Scholar Fried, M. & Duffy, P. E. Adherence of Plasmodium falciparum to chondroitin sulfate A in the human ...
Stages of the malaria parasite that are injected by a mosquito and develop in the liver before emerging into the blood where they can cause symptoms. Vaccines targeting preerythrocytic stages are intended to prevent infection altogether and, if... ...
The TPP proposes intentional and systematic data collection from the pre-registration stages of development through post-licensure to inform on the benefit:risk balance of new treatments for severe malaria during pregnancy. Initially, this involves efficient in vitro screening and prioritization of lead ...
which creates a new niche for binding of infected erythrocytes during pregnancy. Early work from Fried and Duffy showed that the malaria parasites accumulate in the placenta by binding to a glycosaminoglycan of chondroitin sulfate type A (CS) abundantly present in the placenta7. Later, it was ide...
Pregnancy malaria is caused by Plasmodium falciparum-infected erythrocytes binding the placental receptor chondroitin sulfate A (CSA). This results in accumulation of parasites in the placenta with severe clinical consequences for the mother and her unbo
Department of Medical Oncology, Barts Health NHS, London, EC1A 7BE, United Kingdom David Propper & Jonathan Shamash School of Medical Sciences, University of New South Wales, Sydney, NSW, 2052, Australia Christopher Heeschen Contributions
POC platforms have already been realized in the form of lateral flow immunoassays (pregnancy tests) and paper fluidic colorimetric assays [5]. Unfortunately, the aforementioned POC devices are based on capillary flow, and therefore do not work well when more complex multi-step bioassays are ...