et al., “Direct Mechanical Measurements of the Elasticity of Single DNA Molecules by Using Magnetic Beads,” Science, Nov. 13, 1992, 258:1122-6. (Exhibit 15). ;Nov. 13, 1992, 258:1122-6. (Exhibit 15). Sternberg, Brigette et al., “New Structures in Complex Formation Between DNA ...
Cooperativity in A-tract structure and bending properties of composite TnAn blocks The existence of intrinsically curved DNA molecules incorporating short runs of adenines is undisputed, but none of the current models can explain the enti... TE Haran,DM Crothers - 《Biochemistry》 被引量: 96发表...
The design of self-replicating molecules The relevance of autocatalysis to the molecular origins of biological metabolism is discussed as well as important considerations for the design of 'self-replicating' molecules. Typically, the source of autocatalysis is the template effe... M Morgan Conn,J Re...
The transformer [1] is a well-known deep neural network (DNN) model, which has revolutionized the artificial intelligence (AI) field. The architecture of the transformer builds the backbone of large language models (LLM), enabling them to harness the power of vast amounts of data to gain a...
Indeed, the poor solubility of organic pigments is key for their performance (e.g. light/weather fastness, migration resistance), and it is achieved by avoiding solubilising groups in the pigment molecules (Herbst et al., 2005; Bäumler, 2015). However, the properties of organic pigments ...
enhanced cohesiveness, entrapping the flavor molecules within the food matrix during chewing131,137. The flavor-masking effects of dextran are concentration dependent, i.e., the taste and aroma intensities are reduced when dextran is added at levels higher than the critical coil overlap concentration...
“We have a lot of activity across all the different types of therapeutics – small molecules still have a role, targeted antibody treatments have been highly dominant, and immuno-oncology and cell and gene therapies, which are considered by many to be the most promising areas of research...
Process optimization is one of the main goals of modeling. In this regard, the development of data-based models such as MLP is a step towards achieving this goal. Presently, the use of multi-objective optimization (MOO) has found a special place in many continuous, semi-batch and batch pro...
mdpi_layout_typeThis cookie is used to store user setting of using fixed desktop layout instead of the default responsive layout Maximum Storage Duration: 1 yearType: HTTP Cookie settingsThis cookie is used to determine the preferred language of the visitor and sets the language accordingly on the...
The second usage was to discover the structural features of compounds responsible for their inhibitory activities to PTP1B. The derived features are similar to the concept of 'pharmacophore models' and can be used in the prediction and design of better compounds.Jing Wang...