These trends coincided with the increasing use of other psychoactive drugs.doi:10.1111/jgs.18580Kim, Dae Hyun1200 Ctr StLee, HeminHarvard UniversityPawar, AjinkyaLee, Su BeenPark, Chan MiLevin, RaisaMetzger, EranBateman, Brian T.Ely, E. WesleyPandharipande, Pratik P.Pisani, Margaret A....
· Atin Kalra1 · Satish Sardana1 · Pradip Nirbhavane1 Received: 23 September 2024 / Accepted: 21 February 2025 © The Author(s) 2025 OPEN Abstract The pharmaceutical sector has taken a significant lead in last few decades with development of more effective and safe drugs...
Major depressive disorder (MDD) is widely acknowledged as a significant global mental health challenge [1,2]. With a lifetime prevalence of 10 percent, MDD ranks first in prevalence among all mental illnesses and is one of the leading contributors to the global morbidity burden [3]. MDD, a ...
Major Depressive Disorder (MDD) is one of the most common psychiatric disorders, mainly characterized by anhedonia and disturbed mood affecting the patient's quality of life and psychological state and has implications for their social and economic conditions1. Due to its increasing prevalence, chroni...
N-Methyl-D-aspartate receptors (NMDARs) in the brain are influenced by psychoactive drugs such as 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one (ketamine) and its analog 2-(ethylamino)-2-(3-methoxyphenyl)-cyclohexanone (methoxetamine). The recreational methoxetamine use can cause several ...
(4) electroconvulsive therapy within 2 months before scanning, (5) history of seizure or head injury, (6) neurological disorder, (7) current severe physical illness, (8) use of psychoactive drugs/medication <4 weeks before assessments. Incidental benzodiazepine use was allowed, but had to be ...
2. MDD caused by organic mental disorders, schizophrenia, bipolar disorder, psychoactive substances, and non-addictive substances. 3. Subjects exhibiting suicidal ideation. 4. Subjects who are either pregnant or lactating. 5. Subjects with intellectual disabilities who are unable to comply with the ...
Describe three important functions of the self. Give examples of each. What are the three primary characteristics of entitativity? What are the four types of psychoactive drugs? What are three factors that interfere with the communication process? Consider divided consciousness. Discuss how hypnosis ...
Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease that affects an estimated 300 million people worldwide, but its pathogenesis is poorly understood. The heritability estimate of MDD is 30–40%, suggesting that gene
Among analgesic drugs, the opioid class of compounds still remains one of the most important medicines for severe and chronic pain treatment. Hence, developing novel and effective synthetic method of morphine and its related compounds is still an important task in modern synthetic organic chemistry. ...