This structure is added early during the transcription of RNA polymerase II genes in the nucleus =-=(4)-=- and is required for several steps of mRNA biogenesis which include (i) protecting the mRNA against 5� exonucleases, (ii) stimulating translation, (iii) stimulating precursor mRNA splicing, (iv) enhan...
The first steps toward gene manipulation are thought to have been taken in 1944 when Avery and his associates first demonstrated that genetic information is stored in nucleic acid and not protein as previously believed [7t]. In 1952 Hershey and Chase proved that genetic information is transferred...
A subset of 20 fish (10 mock- and 10 VNN-infected) of the ones with RNA-seq data were used to assess chromatin accessibility using ATAC-seq in brain and head kidney tissues. In the major QTL region, four open chromatin regions were identified in the head kidney and three in the brain,...
The EWOD driven microfluidic platform has been applied in various biological engineering applications. For instance, mass spectrometry, which is an important technique for proteomics, requires tedious processing steps including reduction, alkylation, and enzymatic digestion. The lack of a standard sample ha...
Improvements to Google's dictation feature are coming in February, but you can take advantage of voice typing today by following these steps.
The T0 strain acquired a known gain-of-function mutation (V877F) in transcription factor MRR1 (20), a positive transcriptional regulator of the multidrug efflux pump gene MDR1; consistent with this, MDR1 expression was upregulated 5.3-fold (Table S1; Fig. S3). The hypermistranslating T1 ...
To address this we have used chemical nucleases tethered to the polymerase to monitor conformational changes, and engineered disulfide bonds to block conformational changes at defined steps in transcription. We find that many of the major structural transitions occur cooperatively, at a point coincident...
(DNMTs), transcription levels of somatostatin (SST), fatty acid desaturase (FADS); (V) the structural and functional brain remodeling hypothesis: the postmortem results of patients with MDD are mostly associated with the reduced densities of glial cells in the prefrontal cortex (PFC), hippocampus,...
The EWOD driven microfluidic platform has been applied in various biological engineering applications. For instance, mass spectrometry, which is an important technique for proteomics, requires tedious processing steps including reduction, alkylation, and enzymatic digestion. The lack of a standard sample ha...
Over-expression of ORCA2 and ORCA4 transcription factors in hairy roots of Catharanthus roseus boost up 2–40 fold expression levels of both indole and seco-iridoid pathway genes which re- sulted into higher accumulation of tabersonine, ajmalicine and catharanthine as compared to control [15, ...