The immune system has tailored its effector functions to optimally respond to distinct species of microbes. Based on emerging knowledge on the different effector T-cell and innate lymphoid cell (ILC) lineages, it is clear that the innate and adaptive immune systems converge into 3 major kinds of...
Mommaas AM, Koning F (1995) Immunoelectron microscopic analysis of major histocompatibility class II expression on human Langerhans cells. In: Moll H (ed) The im- mune functions of epidermal Langerhans cells. Springer-Verlag, Berlin Heidelberg New York, pp 73–85...
including exhausted T cells18, reduced CD4+and CD8+effector memory cell numbers18,19and elevated PD1 expression on central memory cells, persisting for at least 13 months19. Studies have also reported highly activated innate immune cells, a lack of naive...
Major functions of B and T cells FP99 FIRAS1MH 222024-01 3 Major Histocompatibility ComplexⅠ and Ⅱ FP93 FIRAS1MH 242024-01 4 Innate vs Adaptive Immunity FP97 FIRAS1MH 342024-01 5 Thymus FP96 FIRAS1MH 212024-01 6 Spleen FP96 FIRAS1MH 242024-01 7 Lymphoid Structures 23P94 FIRAS1MH 24...
These results strongly suggest potential anti-inflammatory and mucosal protective functions of cHMOSs in PAMP or IL-1b-stimulated immature intestine. This is consistent with, and may account for, the decreased incidence of infant inflammatory diseases among breast-fed infants, including NEC, asthma, ...
Gffcompare (version 0.12.6) [37] was used to count the number of reads mapped to each gene, and then FPKM was calculated. To annotate the obtained genes and predict their functions, a comparative analysis was performed using the Blast program against the NR database. This approach allowed ...
Themajor histocompatibility complex(MHC) is one of the most intensively investigated, genetically diverse regions of the genome. In its extended form, it encodes more than 400 genes critical to immunity but is also involved in many other functions. In 2009, three simultaneously published genome-wide...
(I) HPA axis dysfunction hypothesis: high levels of glucocorticoids (GCs) play a core role in the pathogenesis of MDD, and thyroid hormone (TH) and estrogen are also involved in functions of the HPA axis; (II) the monoamine hypothesis: the functional deficiency of serotonin (5-HT), ...
While the MR approach can provide evidence for potential causality, we cannot disentangle the effects of trans vs classical signalling, mechanisms for divergent effects of classical signalling on various inflammatory diseases, or the non-immune functions of IL-6, based on MR findings alone. Therefore...
functionally through mammalian evolution, indicating its necessity in ensuring an effective immune system for members of this class. Although MR1 will be celebrating 21 years this year since its discovery, most of our understanding of how this molecule functions has only been uncovered in the past ...