Demographic and baseline clinical characteristics were comparable between the treatment groups (Table1). Most patients in the zuranolone+ADT and placebo+ADT groups were female (60.8% and 64.2%, respectively), White (72.2% and 77.1%, respectively), and had a history of antidepressant use (54.2%...
“We forecast large differences in global DALY burden between different alternative scenarios to see what is the most impactful on our overall life expectancy data and DALY forecasts,” said Dr. Stein Emil Vollset, first author of the study who leads the GBD Collaborating Unit at the Norwegian ...
However, although the FDA in 2008 and the EMA in 2012 attempted to standardize the MACE endpoint definition for RCTs, we found a continued discordance between how observational studies define MACE. Furthermore, we found that the majority of studies did not include mention of the diagnosis ...
Immix Biopharma, Inc. (ImmixBio) (Nasdaq: IMMX) is a clinical-stage biopharmaceutical company trailblazing cell therapies in AL Amyloidosis and other autoimmune diseases. Our lead cell therapy is FDA IND cleared next generation CAR-T NXC-201, currently being evaluated in our...
Characterization of the CDAA Diet-Induced Non-alcoholic Steatohepatitis Model: Sex-Specific Differences in Inflammation, Fibrosis, and Cholesterol Metabolism in Middle-Aged Mice Front Physiol. 2021 Feb 22;12:609465. Dora Szabo, Zsolt Sarszegi, Beata Polgar, Eva Saghy, Adam Nemeth, Dora Reglodi, ...
Time was included as a categorical variable, and a treatment × time effect was included to evaluate between-group differences in mean scores at each point. Sensitivity analyses using multiple imputation methods were run for the primary and key secondary outcomes. Sustained depressive symptom ...
answer outstanding questions, such as whether effects on anhedonia will hold up in larger trials, whether there are specific patient populations with DYN/KOR dysfunction, whether efficacy will vary between in men and women, and whether differences will be seen between monotherapy and adjunctive ...
The isolation of enantiomeric S-ketamine (esketamine), which has a four-fold higher affinity to N-methyl-D-aspartate (NMDA) receptors, and its availability as an intranasal spray approved by the FDA and EMA for use in adult TRD, could present a more practical option compared to intravenous ...