substance use, major depressive disorder (either single episode or recurrent), bipolar disorders, and more rarely schizoaffective disorder. Thus, it is important to collect a thorough history and medical examination to rule out these other conditions before making a diagnosis of major depression. ...
van Eijndhoven, P., van Wingen, G., Fernandez, G., Rijpkema, M., Pop- Purceleanu, M., Verkes, R.J., Buitelaar, J., Tendolkar, I., 2012. Neural basis of recollection in first-episode major depression. Hum. Brain Mapp.
Single-dose psilocybin for a treatment-resistant episode of major depression. N Engl J Med. 2022;387(18):1637-1648. doi:10.1056/NEJMoa2206443PubMedGoogle ScholarCrossref 15. von Rotz R, Schindowski EM, Jungwirth J, et al. Single-dose psilocybin-assisted therapy in major ...
For this post-hoc analysis, we defined our clustering variables as: (1) duration of index episode: Collected retrospectively and measured in days. (2) Depression severity: Assessed at the time of consultation using the item for depression of the CGI-BP (CGI-BP-D)42 which evaluates how ...
But major depression is different, both in its timing -- near daily sadness that sticks with you for 2 weeks or more -- and its intensity. Antidepressants and talk therapy are the two pillars of depression treatment. But while you explore your options with a mental health professional, you ...
As a stress-related disorder, major depression is associated with an abnormal stress response system. For example, excessive cortisol release in response to stress and impaired GR-mediated feedback inhibition have been known for decades.120,121The NR3C1 gene encodes for the GR,122,123which is an...
(2011) investigated first-episode major depression whereas our patients as well as the patients in Wang et al. (2017) were ill for an average of 34 and 41 months, respectively. Indeed, most of our patients (36/53) experienced chronic illness duration (> 12 months) and all patients ...
production of pro-inflammatory cytokines and an interferon response that was correlated with anxiety and depression-like behaviours in the hamsters, with similar transcriptional signatures found in the tissue of humans who had recovered from COVID-19 (ref.93). Infected non-human primates with mild ...
= −0.17), compared with healthy controls, whereas no hippocampal volume alterations were observed in first-episode patients (N = 583). Our findings may suggest that depression-related reductions in hippocampal volume are a result of longer illness duration or greater number of episodes...
Adult patients with recurrent depression (N=1302) compared to controls (N=7450) revealed cortical thinning in left medial OFC (Supplementary Figures S2 and S12). First-episode patients (N=535) compared to controls (N=7253) showed more widespread cortical thinning in bilateral fusiform gyrus, rost...