There are also arguments to be made in favor of designing studies to collect specific groups of patients, focusing on one sex, on recurrent depression and hospital rather than community ascertainment. Analysis of between-cohort genetic heterogeneity using data from 29 independent component cohorts of ...
To evaluate the clinical efficacy and safety of Agomelatine in improving symptoms in patients with major depressive disorder (MDD), providing more scientific evidence for the treatment of depression, and offering more effective therapeutic options for patients. Methods A total of 180 MDD patients in ...
The structural equation modeling analysis showed that knowledge, but not attitude (β = 0.103, P = 0.092) or practice (β = 0.034, P = 0.603), influenced the depression level (β=-0.074, P < 0.001); attitude influenced practice (β = 0.369, P < 0.001)...
Further, a blunted RewP can prospectively predict increases in depressive symptoms (Freeman et al., 2022b), depression onset (Bress et al., 2013; Nelson et al., 2016), and first episode of recurrent/chronic depression (Michelini et al., 2021). Combined, these data suggest that the RewP...
ICD-11: a major step forward towards the prediction and prevention of chronic postsurgical paindoi:10.1097/EJA.0000000000001996Esther M.,Pogatzki-ZahnPatrice,ForgetLippincott Williams & WilkinsEuropean journal of anaesthesiology
time the determination of a close-meshed time course of many peripheral blood and neuropsychological parameters in parallel to depression severity, taking into account the large data base showing that the onset of antidepressants' action takes place in the first 10-14 days after treatment initiation....
Our consortium data are derived from adults with first episode or recurrent MDD, medication-free, in a current major depressive episode, that is not treatment-resistant depression, and healthy controls. We leverage statistical harmonization, machine learning and deep learning methods and large ...
Major depression is associated with altered static functional connectivity in various brain networks, particularly the default mode network (DMN). Dynamic functional connectivity is a novel tool with little application in affective disorders to date, and holds the potential to unravel fluctuations in conn...
Depending on its longitudinal course, major depression can appear as single or recurrent episodes (unipolar major depressive disorder, MDD) or alternating with episodes of *Correspondence: Dr M Grataco` s, Genes and Disease Program, Center for Genomic Regulation (CRG), Charles Darwin s/n (Dr ...
Unipolar depression 31 86.1 33 89.2 Bipolar depression 5 13.9 4 10.8 0.689a Psychotic symptoms 8 22.2 10 27.0 0.634a Melancholic symptoms 34 94.4 36 97.3 0.615b Co-morbid anxiety disorder 9 25.0 9 24.3 0.947a Previous alcohol abuse 5 13.9 3 8.1 0.479b First episode before the age of 60...