Major depressive disorder (MDD) (also known as recurrent depressive disorder, clinical depression, major depression, unipolar depression, or unipolar disorder) is a mental disorder characterized by an all-encompassing low mood accompanied by low self-esteem, and by loss of interest or pleasure in ...
[3] Episodes may be isolated or recurrent and are categorized as mild (few symptoms in excess of minimum criteria), moderate, or severe (marked impact on social or occupational functioning). An episode with psychotic features—commonly referred to as psychotic depression—is automatically rated as...
Altered functional connectivity in first-episode and recurrent depression: A resting-state functional magnetic resonance imaging study. Front Neurol. 2022;13:922207. Article PubMed PubMed Central Google Scholar Zheng Y, Chen X, Li D, Liu Y, Tan X, Liang Y, Zhang H, Qiu S, Shen D. ...
4 Depression can be accompanied by recurrent seizures, which may occur even during remission or persist for longer than the disease itself.5 Pharmacological therapies for MDD can effectively control symptoms; thus, patients may experience recurrence within a short time after discontinuing medication.6 ...
Autobiographical memory in the euthymic phase of recurrent depression. J Abnorm Psychol. 2006;115(3):590-600. doi:10.1037/0021-843X.115.3.590PubMedGoogle ScholarCrossref 5. Gibbs B, Rude S. Overgeneral autobiographical memory as depression vulnerability. Cognit Ther Res. 2004;...
which may be related to genetic, psychological, and social factors.4Depression can be accompanied by recurrent seizures, which may occur even during remission or persist for longer than the disease itself.5Pharmacological therapies for MDD can effectively control symptoms; thus, patients may experience...
35 Moreover, compared to previous trials,33,34 here we had more participants with recurrent depression and longer depressive episodes, which have been associated with greater treatment resistance.36 In this regard, tDCS has indeed displayed lower antidepressant effects in more treatment...
To evaluate the clinical efficacy and safety of Agomelatine in improving symptoms in patients with major depressive disorder (MDD), providing more scientific evidence for the treatment of depression, and offering more effective therapeutic options for patients. Methods A total of 180 MDD patients in ...
Note: This figure shows individual pre- and post-MBCT depression scores and least square regression lines for the different transition paths. The different panels (A–D) compare patients whose mindfulness profile changed versus those patients that do not change in mindfulness profile, that had pre-...
Major depression is associated with altered static functional connectivity in various brain networks, particularly the default mode network (DMN). Dynamic functional connectivity is a novel tool with little application in affective disorders to date, and holds the potential to unravel fluctuations in conn...