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affect yields and, if not managed properly, yield losses are reported of up to 80%3,4. Chemical control in Brazil to manage the disease started in the 2002/03 growing season4. In the following season, ~20 million hectares of soybeans were sprayed with fungicides to control this disease (...
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Previous work has successfully used congener composition within chemical classes such as polychlorinated biphenyls (PCBs) to identify the origin of major human exposure sources [28,29,30]. Applying such techniques to PFASs is complicated by dramatic shifts in production over time and the complex ...
Physico-chemical parameterLinear B-cell epitopes Hydrophilicity SVDSSSTHRRR, ADPRPGSARS, STEDLTD, TNEKRDI, EGFSNTD, SVPSEEG, REQYGCDT, EVEDQGGAGSAGS, MRNAQDE, FCNESEDAI, YSDGSCTQRASEA, RPKATDG, QCDTATRT, QVHGSNDYTNCT, QAAKDGGNTAAGR Flexibility MSVDSSSTHR, AAADPRPGSA, DILTNEK, NVPNVRG...
The development of new approach methodologies (NAM), including advanced in vitro 3D models based on human cells (e.g. spheroids, organoids), and microphysiological systems (e.g. organ-on-a-chip), can provide valuable information on chemical/biochemical hazard and risk safety assessment (Cattaneo...
To validate the microarrays, normal distribution analysis was performed with the results of the nine microarrays, and all of their coefficients were <0.5. Based on the 595 known genes that were shared as DEGs in both breeds, cluster analysis of all microarrays was performed (Figure 2) using th...
A prime example for the latter is the discovery of the acidic sphingomyelinase (ASM) as a target of several antidepressants, which evolved from the observation that antidepressants, due to their chemical nature, accumulate in lysosomes [67,247]. ASM cleaves sphingomyelin into ceramide and phos...
Epigenetics refers to short- and long-term gene expression variations that are caused by non-DNA-encoded mechanisms.30,31These mechanisms include DNA methylation or hydroxymethylation, chemical changes occurring on histone proteins (histone modification), expression of noncoding RNAs, chromatin remodeling,...