After wounding, multiple cell types interact to form a fibrovascular scar; the formation and cellular origins of these scars are incompletely understood. We used a laser-injury wound model of choroidal neovascularization in the eye to determine the spatiotemporal cellular events that lead to ...
Host macrophages are a barrier to the engraftment of embryonic stem cell-derived hematopoietic progenitors. (P4544) Taken together, our data demonstrate that F4/80+ M are a barrier to ES-HP engraftment and suggest that cultured ES-HPs are unable to regulate host M phagocytosis. In line with ...
Dendritic cells (DCs) and macrophages are critical to innate and adaptive immunity to the intestinal bacterial microbiota. Here, we identify a myeloid-deri... JH Niess,Stephen Brand,X Gu,... - 《Science》 被引量: 4110发表: 2005年 Transepithelial transport and mucosal defence I: the role of...
Macrophages exist in various tissues, several body cavities, and around mucosal surfaces and are a vital part of the innate immune system for host defense against many pathogens and cancers. Macrophages possess binary M1/M2 macrophage polarization settings, which perform a central role in an array ...
Macrophages are critical mediators of tissue homeostasis, with tumours distorting this proclivity to stimulate proliferation, angiogenesis and metastasis. This had led to an interest in targeting macrophages in cancer, and preclinical studies have demonstrated efficacy across therapeutic modalities and tumour ...
Multiple sclerosis (MS) is a chronic immune-mediated disease characterized by inflammation, demyelination, gliosis, and neurodegeneration in the central nervous system (CNS) [1]. It is estimated that over 2.8 million people are living with MS worldwide [2] and the prevalence of MS is projected...
The ES cell-like cells could be passaged only mechanically and did not form colonies when plated as single cell suspension at different concentrations. When F-ES cell-like, NT-ES cell-like, and BAF cells of same genotype were used for hand-made cloning (HMC), no significant difference (p...
Leishmania are trypanosomatidae which under their amastigote form behave as obligate intracellular parasites. At this stage, they multiply in macrophages of infected mammals (including man), within parasitophorous vacuoles (PV). These organelles of macrophage origin are part of the endocytic pathway. ...
macrophages are derived from bone marrow stem cells in response to monocyte colony stimulating factor to form monocytes (the precursor of macrophages), circulating in the blood. After initiation of inflammation, they migrate to inflammatory tissues and mature into macrophages and perform their function ...
Modulation of the host’s immune status is very crucial in the host-pathogen relationship. Several molecules of the pathogen are responsible for host immunomodulation. Gram-negative pathogens carry an arsenal of antigens that can trigger a multitude of cellular responses (Fallon, 2009, Sakharwade et...