We conclude that macrophages are unable to use the endogenous class II presentation pathway for these two model self-antigens. As a consequence MHC class II-restricted T cells specific for C5 and alpha 1-antitrypsin remain ignorant of the presence of self-antigen within macrophages and are ...
Class II MHC protein expression in macrophages (M phi) is reduced during tumor growth. Because regulation of class II MHC proteins occurs during transcription, tumor growth may suppress class II MHC protein expression by suppressing mRNA. The decrease in class II mRNA may result from (i) a dec...
2003. Regulation of the class II MHC pathway in primary human monocytes by granulocyte-macrophage colony-stimulating factor. J. Immunol. 171: 2374- 2383.HORNELL T M;BERESFORD G W;BUSHEY A;.Regul-ation of the class Ⅱ MHC pathway in primary human monocytes by granulocyte-macrophage colony-...
[5]. Stimulation of M1 macrophages results in high secretion levels of IL-1b, TNF-α, IL-12, IL-18, and IL-23. Moreover, the M1 macrophage phenotype has been shown to express high levels of major histocompatibility complex class II (MHC II), CD68, CD80, ...
[5]. Stimulation of M1 macrophages results in high secretion levels of IL-1b, TNF-α, IL-12, IL-18, and IL-23. Moreover, the M1 macrophage phenotype has been shown to express high levels of major histocompatibility complex class II (MHC II), CD68, CD80, ...
While MHC class II expression is correlated with classical M1 phenotype, high or low MHC class II expression did not correlate with altered macrophage activation state at different time points after sciatic nerve crush. In addition, in this study, Relmα, Mgl2, Ym1 and arginase that are ...
(Th1, CD8+ T cells), NK cells Macrophages: classical activation; B cells: isotype switching to opsonizing and complement-fixing IgG subclasses (established in mice); T cells: Th1 differentiation; Various cells: increased expression of class I and class II MHC molecules, increased antigen ...
Immunohistochemical Analysis of MHC Class 2 (HLA-DR / DP), ICAM-1, CD68(+) Macrophage Expression in Gastric AdenocarcinomaPURPOSE: Gastric adenocarcinoma is the most common malignant tumor in Korea and immunochemotherapy can be alternative... ES Park,SN Kim,TJ Lee,... 被引量: 0发表: 1998年...
LPMs are predominant and exhibit elevated F4/80 expression but low MHC class II (MHC-II) expression. In contrast, SPMs display lower levels of F4/80 but higher expression of MHC-II. Interestingly, during inflammatory responses, SPMs exhibit heightened expression of the chemokine receptor CCR2 ...
Moreover, the M1 macrophage phenotype has been shown to express high levels of major histocompatibility complex class II (MHC II), CD68, CD80, and CD86, as well as of the Th1 cell-attracting chemokines, including CXCL9 and CXCL12 [12]. Table 1. Human M1 macroph...