Bone marrow (BM) fibrosis in myeloproliferative neoplasms (MPNs) is associated with a poor prognosis. The development of myelofibrosis and differentiation of mesenchymal stromal cells to profibrotic myofibroblasts depends on macrophages. Here, we compared macrophage frequencies in BM biopsies of MPN ...
However, after recognition of the bone marrow origin of macrophages the concept of the mononuclear phagocyte system has been developed which comprises mature macrophages as well as their precursors in peripheral blood and bone marrow. The cells of the mononuclear phagocyte system form a heterogeneous ...
A resident population of macrophages evidently is set up very early in these organs, well before white cells colonize the spleen, bone marrow, and other future blood forming regions. The events outlined are seen as stages in an embryo-wide process that leads to establishment of macrophage ...
The aim of this method was to easily obtain large numbers of macrophages in few days. The bone marrow cell preparation is illustrated inFigure 1. Bones from the hind leg were collected and smashed in a mortar. Once the resident macrophages were removed from the bone marrow cell preparation, ...
In addition, ActA's impact on OCL development is most significant during early osteoclastogenesis, similar to IL-3,3 and consistent with our current data demonstrating that both IL-3-induced ActA production by CD14 þ BMM and expression of the IL-3R on OCL precursors decrease during OCL ...
This indicates that bone marrow cells accumulate in the liver and differentiate into liver macrophages on site. Roles of factors secreted from hepatocytes are also discussed. 展开 关键词: Kupffer cells liver macrophage differentiation macrophage proliferation PKH-26 ...
Using mAb and magnetic and fluorescence-activated cell sorting, together with culturing in semisolid culture medium, we show that essentially all splenic macrophage progenitors are Ly-6ChiMac-1-. By contrast, bone marrow macrophage progenitors were more heterogeneous in Ly-6C expression, the majority...
Marlene S.Magalhaes, ...RebeccaGentek, inInternational Review of Cell and Molecular Biology, 2022 Abstract Macrophagesare central elements of all organs, where they have a multitude of physiological and pathological functions. The first macrophages are produced duringfetal development, and most adult o...
Here, we investigated the role of M1/M2s in crystal development by usingin vitroandin vivoapproaches. The crystal phagocytic rate of bone marrow-derived M2Mφs was higher than that of bone marrow-derived Mφs and M1Mφs and increased on co-culture with renal tubular cells (RTCs). However...
Use of recombinant hematopoietic growth factors in the course of bone marrow transplantation has revolutionized this modality by significantly improving the safety of the procedure. It is anticipated that use of cytokines in combination ... HM Lazarus - 《Cancer Treat Res》 被引量: 10发表: 1997年...