particularly heart defects, than children of mothers who took penicillin, in a study published in The BMJ .1 Macrolide antibiotics (including erythromycin, clarithromycin, and azithromycin) are used to treat common bacterial infections and are considered alternatives for patients with penicillin allergy....
Erythromycin is a macrolide antibiotic often used in children with minor bacterial infections, especially in those with an allergy to penicillin. Objective To evaluate the effects of six macrolide antibiotics against mycobacteria . Tulathromycin is a novel macrolide antibiotic for animals which has been...
The antimicrobial spectrum of macrolides is broader than that of penicillins (and comparable to many late-generation cephalosporins); therefore, macrolide antibiotics have been successfully used as a substitute in treating patients with known penicillin allergy [3]. Adverse reactions with macrolide ...
Macrolidesare a family of drugs that are similar in their antibacterial spectrum tophenoxymethylpenicillinand are usually reserved for patients who are allergic topenicillin. The most common macrolide antibiotics used indentistryareerythromycin(category B),azithromycin(category B), andclarithromycin(category...
Viral infection of human lung epithelial cells The A549 cells were maintained by passages with Dulbecco's modified Eagle's medium (Sigma Aldrich Japan, Tokyo, Japan) supplemented with 10% fetal bovine serum (Mexico origin, Gibco) and 1% penicillin/streptomycin (Gibco). The A549 cells were ...
Conditional GWAS identifies a resistance mutation in RplD To identify these variants, we re-analyzed the GWAS results focusing on the remaining unitigs, which had lower effect sizes andp-values closer to the Bonferroni-correctedp-value threshold, calculated using the number of unique patterns, of ...
Penicillin is effective treatment, but azithromycin (a macrolide) is a single-dose oral alternative for those with allergy. Unfortunately, macrolide resistance secondary to one of two 23S ribosomal RNA (rRNA) point mutations (A2058G and A2059G) is now wide-spread. Molecular strain-typing ...
Although penicillin is the drug of choice in streptococcal tonsillopharyngitis, macrolides are recommended drugs in patients who have an allergy to penicillin. However, resistance to macrolides is an important problem in some regions of the world. Risk factors for resistance development have not been...
(HMR 3004) was synthesized at Roussel Uclaf.89This ketolide was stable in acidic media, showed good intracellular penetration, and demonstrated potent activity against erythromycin A resistant andpenicillinresistantstreptococciandH. influenzae. SystematicSARstudies led to the discovery of several ketolide ...