Mishima, H.: Milbemycin: A family of macrolide antibiotics with insecticidal activity, in: Pesticide Chemistry Human Welfare and the Environment, Vol. 2 (ed.) Miyamoto, J. and Kearney, P. C., p. 129, Oxford, Pergamon 1983Mishima M, Milbemycin: a family of macrolide antibiotics with ...
macrolide antibioticsnargenicinpolyketidesThe nargenicin family of antibiotic macrolides comprise a group of bacterial natural products with a rare ether bridged cis ヾecalin moiety and a narrow spectrum of activity. The majority of family members were identified almost four decades ago and were ...
Macrolidesare one of the most commonly used families of antibiotics prescribed to treat infections caused by Gram-positive bacteria such asS. aureus, S. pneumoniaeandS. pyogenes(Gaynor and Mankin, 2005).Macrolidesare bacteriostatic and inhibit protein synthesis. Although their exact mechanism of action...
The renewed interest in macrolide antibacterials with expanded indications for clinical use, as well as their markedly increased usage, justifies the continuous search for new compounds designed to offer the patient not only enhanced bioavailability but also a reduced incidence of adverse effects. Macroli...
This implicated structural divergence of the appended sugar wherein the 43 AMU The Journal of Antibiotics Venturicidin C, a new 20-membered glycosylated macrolide KA Shaaban et al 226 Table 2 1H NMR spectroscopic data of venturicidins C (1), A (2) and B (3) Position 2 3-OH 4 5 6...
The Erm family of methyltransferases is responsible for the development of resistance to the macrolide-lincosamide-streptogramin type B (MLS) antibiotics. These enzymes methylate an adenine of 23S ribosomal RNA that prevents the MLS antibiotics from bind
Milbemycins, a new family of macrolide antibiotics: fermentation, isolation and physico-chemical properties. They are produced in submerged cultures of Streptomyces hygroscopicus subsp. aureolacrimosus. Fermentation studies on the strain were conducted in shaken flasks... Takiguchi,Mishima,Okuda,... - ...
(MICs) of solithromycin in drug-resistant or multi-drug-resistant strains of clinical isolates (methicil- lin-resistant S. aureus and macrolide-lincosamide-strep- togramin B-resistant Streptococcus pneumoniae) are comparable or generally lower than those of other regu- larly used antibiotics, such...
Strikingly, 4 of 30 SNPs causing non-synonymous mutations were clustered in macrolide-specific efflux system gene macB encoding macrolide-specific efflux pump protein of the ATP-binding cassette transporter family. In assays of the minimal inhibitory concentrations (MIC) of macrolide antibiotics in the...
It is another aspect of the present invention to describe a family of unique Amphotericin B analogues that have the ability to disrupt the membrane integrity of representative fungal cells, and may thus be characterized as antifungal agents. ...