Macrocytosis with normal hemoglobin and hematocrit.Focuses on the significance of findings of patients who developed macrocytosis without a drop in hemoglobin or hematocrit. Pathogenesis of macrocytosis; Role of vitamin B12 and folate deficiency in the etiology.R.M.D....
Macrocytosis is a term used to describe erythrocytes that are larger than normal, typically reported as mean cell volume (MCV) greater than 100 fL. The amount of hemoglobin increases proportionately with the increase in cell size. Therefore, if the increase in MCV is not related to macrocytic ...
30% of persons with African ancestry in the United States have one deleted α hemoglobin subunit and their median MCV is about 84 fL. It would take much longer for these individuals to increase the MCV to greater than 100 fL than someone whose normal MCV was 92 fL. Persons with β-thalas...
Stricter attention to the established limits of normal hemoglobin values is required. These aspects of physician performance have implications for the recognition of all anemias. ( Arch Intern Med 139:47-50, 1979)doi:10.1001/archinte.1979.03630380031013Ralph...
9 cases (20.9%) of Vitamin B12 deficiency presented with isolated macrocytosis without anemia. It was observed that mean hemoglobin was lower and red cell distribution width (RDW) higher in megaloblastic conditions. Peripheral smear revealed hypersegmented neutrophils in 86% and macro-ovalocytes in...
This different pattern in iron supplemented pregnancies was due to an increase in the red cell count together with a change in mean cell volume. Although the changed mean cell volume usually remained within the normal range in the group who did not take iron, a few women developed micro...
The results were as follows: (1) In severe phenylhydrazine anemia, red cell volume and hemoglobin content per cell increased to twice the normal values. (2) The RNA level of normoblasts decreases with the maturation of the cells and reaches a minimum at the orthochromatic stage. The ...
His patient, probably suffering from pernicious anemia, had 414,062 red cells per cubic millimeter of blood with a hemoglobin value of 554,840 normal cells and a color index of 1.34. Eichhorstdoi:10.1001/jama.1932.02730290018005RUSSELL L. HADEN...
Reference values for mean corpuscular volume and mean corpuscular hemoglobin level derived from normal populations may be inappropriate for children with Down syndrome. These findings may have important implications for the diagnosis of iron deficiency in these children.Thomas J. Starc...
The highest MCV ( P < 0.001) and mean cell hemoglobin (MCH) ( P < 0.01) occurred in the alcoholics. However, the values in the moderate drinkers also responded to ethanol intake such that the upper normal limit for MCV based on the data from moderate drinkers was 98 fl, as compared ...