Introduction Inflammation in chronic obstructive pulmonary disease (COPD) is associated with increased numbers of highly activated macrophages with a reduced phagocytic capacity. Macrophages may exist as M1 "classically activated" or M2 "alternatively activated" with different phagocytic and inflammatory ...
巨噬细胞Macrophages一个重要的特性就是具有很高的可塑性(通俗的讲就是多变,随所处环境的变化而变),面对不同的病原体或刺激因素时可以向不同方向分化。根据极化后巨噬细胞的表面标志物及其功能,将其分为M1型(经典活化)巨噬细胞和M2型(替代激活)巨噬细胞两种主要表型。切记,巨噬细胞macrophages的极化M1和M2是机...
M1 AND M2 MACROPHAGES IN POTENTIALLY MALIGNANT DISORDERS AND SQUAMOUS CELL CARCINOMA OF THE ORAL CAVITY AND LIPdoi:10.1016/j.oooo.2017.05.349LEóN, JORGE ESQUICHEDOS SANTOS, JESSICA LUANADA SILVA, ALFREDO RIBEIROCHAHUD, FERNANDOALMEIDA, LANA KEI YAMAMOTO...
The release of neutrophil extracellular traps (NETs) can be either beneficial or detrimental for the host, thus it is necessary to maintain a balance between formation and clearance of NETs. Multiple physiological factors eliciting NET release have been
TNF- αexpression was more in M1 state and Arg1expression was taller in M2 state.Conclusion: The peritoneal macrophage is the best choice among the four species of macrophages. We demonstrated that IL-10 expression may be much higher in LPS and IFN-γ induced M1macrophages than that in M2 ...
Infiltration of macrophages in and around tumor nest represents one of the most crucial hallmarks during tumor progression. The mutual interactions with tumor cells and stromal microenvironment contribute to phenotypically polarization of tumor associate
Cytokine release of M1 and M2 macrophages infected with C. pneumoniae.Tanja, BuchacherAnna, OhradanovaRepicHannes, StockingerMichael, B. FischerViktoria, Weber
The mitochondrial dysfunction and oxidative stress imbalance caused by macrophage polarization play a role in the progression of COPD, with CDGSH iron–sulfur domain-containing protein 1 (CISD1) playing a key role. This study revealed the role and mechanism of CISD1 in smoke-induced macrophages. ...
www.nature.com/scientificreports OPEN Microenvironment M1/M2 macrophages and tumoral progression vary within C57BL/6 mice from same substrain in prostate cancer model P. Hernández‑Peralta 1, R. Chacón‑Salinas 2, M. I. Gracia‑Mora 3, G. Soldevila 4, J....
And M1 macrophages are characterized by subdivision into M1a and M1b [26]. In this case, we analyzed the extreme forms of M1 and M2 macrophages in our study. Macrophage-based cell therapy for various diseases is an emerging field. The current clinical trials devoted to the study of ...