mCPP (meta-chlorophenylpiperazine), an agonist at serotonin (5-hydroxytryptamine, 5-HT) 5-HT2 receptors, has been used as a probe of serotonergic function. We assessed its effect on platelet activation by measuring median platelet volume (MPV), the Sonoclot (SCT) pattern and plasma and ...
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m-Chlorophenylpiperazine (mCPP) and the internal standard, l-(2-pyrimidinyl)piperazine (1PP) are extracted from base matrix using CN sorbent extraction columns. Chromatography and detection are performed using isocratic reverse-phase high performance liquid chromatography (HPLC) with a CN column and ...
Finally, when the specific CYP2D6 inhibitor quinidine was preincubated with either human liver microsomes or cells expressing human CYP2D6, there was a concentration-dependent decrease in the production of OH-mCPP. Conclusions: These results confirm that CYP2D6 is the isoform responsible for the p...
The effects of m-chlorophenylpiperazine (mCPP), a serotonin receptor agonist, on the release of plasma prolactin (PRL), growth hormone (GH), and cortisol in the rhesus monkey were studied. mCPP was administered intravenously at doses of 0.5, 1.5, and 3.0 mg/kg. GH and cortisol were incr...
Administration of m-chlorophenyl-piperazine (m-CPP), a partial serotonin agonist, may lead to acute exacerbation of symptoms of obsessive-compulsive disorder (OCD), whereas administration of the alpha-2 adrenergic agonist, clonidine, may be followed by an acute decrease in symptoms. We studied beha...
Broocks A, Briggs NC, Pigott TA, Hill JL, et al. (1997). Behavioral, physiological and neuroendocrine responses in healthy volunteers to m-chlorophenylpiperazine (m-CPP) with and without ondansetron pretreatment. Psychopharmacology (Berlin) 130, 91-103....
Objectives: This study examined sex differences in the anxiogenic stimu-li induced by a serotonin (5-HT) 1b/2 agonist, meta - chlorophenylpiperazine (mCPP), prior to ethanol and during EW. Methods: Gonadectomized or sham-operated adult male and female rats and 17β-estradiol (2.5 mg, ...
Cortisol responses following m-CPP were not significantly different for bulimic patients vs controls, although there was a trend toward blunted cortisol responses following L-tryptophan administration in the depressed bulimic patients. These differences in neuroendocrine responses were not related to ...
Objectives: This study examined sex differences in the anxiogenic stimu-li induced by a serotonin (5-HT) 1b/2 agonist, meta - chlorophenylpiperazine (mCPP), prior to ethanol and during EW. Methods: Gonadectomized or sham-operated adult male and female rats and 17β-estradiol (2.5 mg, ...