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To provide insight into the mechanisms of this drug resistance, molecular dynamics simulations and free-energy calculations were carried out for complexes of crizotinib with wild-type (WT) ROS1 as well as the mutated L2026M and G2032R forms. MD simulations indicated that the L2026M and G2032...
ORIGINAL PAPERGaining insight into crizotinib resistance mechanisms causedby L2026M and G2032R mutations in ROS1 via moleculardynamics simulations and free-energy calculationsXiaoYun Wu 1 & Yu Fu 1 & YuanYuan Wang 1 & ShanHe Wan 1 & JiaJie Zhang 1Received: 31 October 2016 /...
英菲尼迪G M系ESQ EX FX JX QX70 QX Q50L QX50 Q70遥控器汽车钥匙电池原装原厂专用智能纽扣电子CR2032 3V 已售少于100 ￥19点击查看更多配送: 广东东莞至 阳泉城区 快递: 免运费 保障:7天无理由退货 参数:颜色分类:英菲尼迪车钥匙电池CR2032【2粒】
三根绳a.b.c长度都为l.a.b悬挂在天花板上.c的下端与质量为m=2kg物体相连.它们之间的夹角为120°.如图所示.现用水平力F将物体m缓慢向右拉动.绳a的拉力为T1.绳b的拉力为T2.当绳c与竖直方向的夹角为某一角度时.T2的值恰为零.此时T1=4040N.水平拉力F的大小为203203N.
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