单克隆免疫球蛋白又称为M蛋白或副蛋白,是浆细胞单克隆产生的无功能免疫球蛋白或其轻链或重链片段,多见于多发性骨髓瘤(multiple myeloma,MM)、巨球蛋白血症(macroglobulinemia,WM)和意义不明的单克隆丙种球蛋白血症(monoclonal gammopathy of undetermined significance,MGUS)[1-2]。...
Multiple myeloma (MM) is characterized by excessive production of monoclonal immunoglobulins (M proteins). Routine screening methods for M proteins to assess prognosis are unable to detect low levels of M proteins produced by residual tumor cells, ie, minimal residual disease (MRD). Assessment of ...
主要参考文献 [1] Mills J R , Kohlhagen M C , Surendra D , et al. Comprehensive Assessment of M-Proteins Using Nanobody Enrichment Coupled to MALDI-TOF Mass Spectrometry[J]. Clinical Chemistry(10):10. [2] Kohlhagen M , Dasari S ...
Multiple myeloma.When plasma cells are cancerous and grow out of control, it's called multiple myeloma. These cancer cells build up in the bone marrow and crowd out healthy cells. They also make M proteins. Higher levels of M protein in the blood can lead to complications. Waldenstrom's m...
目的分析1 575例血清免疫电泳阳性患者M蛋白的测定结果,探讨M蛋白检测临床诊断中的价值。 方法实验标本均来自于郑州大学第一附属医院检验科在2016年8月至2017年8月期间的住院门诊送检病例,通过免疫固定电泳技术对标本进行M蛋白检测,对1 575例M蛋白阳性患者的免疫特征指标进行综合分析。 结果1 575例血清免疫固定电泳后出...
Results:A total of 142 patients were included in the study.There were 85 males and 57 females with male predominance,with a median age of 60 0 years.The M⁃proteins in that cohort were 62 0% IgG,24 7% IgA,6 3% IgM,4 9% free light chain,0 7% heavy chain, 1 4% IgG and IgA;...
Immunofixation is also a more sensitive test than protein electrophoresis, and it should always be performed in conjunction with electrophoresis when multiple myeloma or related disorders are first suspected in order to detect small, unmeasurable M proteins that may be missed on electrophoresis. This ...
Multiple Myeloma is a type of cancer that affects plasma blood cells. Healthy plasma cells produce antibodies which are made up of protein.Answer and Explanation: Myeloma cells produce abnormal antibodies that are not functional. These proteins go by a variety of names including M proteins, ...
Arleigh McCurdy Donna Reece Suzanne Trudel Blood Cancer Journal (2024) Just scratching the surface: novel treatment approaches for multiple myeloma targeting cell membrane proteins Paola Neri Noémie Leblay Kenneth C. Anderson Nature Reviews Clinical Oncology (2024)Download...
In MM cells the BCMA activation and downstream signaling cascade functions to upregulate antiapoptotic proteins including Bcl-2, Bcl-xL, and Mcl-1 and protect the cells against therapeutic agents like dexamethasone (2,3). Given its specific expression on plasma cells but not memory B cells, ...