M蛋白，也称monoclonal Protein、monoclonal immunoglobulin、myeloma protein 或 M- spike，是浆细胞或B淋巴细胞异常增殖产生的大量异常免疫球蛋白。这种异常免疫球蛋白通常与多种疾病有关，如多发性骨髓瘤（multiple myeloma）、巨球蛋白血症以及恶性淋巴瘤等，这些疾病的名称均以M开头，因此统称为“M蛋白相关...
M蛋白是浆细胞或B淋巴细胞单克隆恶性增殖所产生的一种大量的异常免疫球蛋白,其本质是一种免疫球蛋白或免疫球蛋白的片段,又叫做monoclonal Protein、 monoclonal immunoglobulin、myeloma protein, or M- spike。 因其多见于多发性骨髓瘤(multiple myeloma)、巨球蛋白血症(macroglobulinemia)及恶性淋巴瘤(malignant lymphoma...
M蛋白是浆细胞或B淋巴细胞单克隆大量增殖时所产生的一种异常免疫球蛋白,其氨基酸组成及排列顺序十分均一,空间构象、电泳特征也完全相同,本质为免疫球蛋白或其片段(轻链、重链等)。由于它产生于单一克隆,又常见于多发性骨髓瘤(MM)、巨球蛋白血症(WM)、恶性淋巴瘤病人的血或尿中,...
for a monoclonal protein (an M spike is seen), a follow-up test is automatically done. It is calledimmunofixation. It is done to identify what sub-type of monoclonal protein is present. It can also identify an M protein that is a piece of antibody, called a light chain M protein. ...
冠状病毒进入宿主细胞的过程,依赖于刺突蛋白(Spike protein)与宿主细胞表面血管紧张素转换酶2(ACE2)受体的结合,之后通过受体引导的内吞作用进入细胞,释放病毒基因组,完成病毒聚合酶的转录,进行基因组复制和结构蛋白的合成,最后组装成完整的病毒颗粒,通过胞吐作用被释放到胞外完成增殖。其基因组进入宿主细胞后,会借助宿主...
The virus consists of four structural proteins: spike (S), small membrane (sM or E), membrane (M), and nucleocapsid (N) proteins (Spaan et al., 1988, Saif and Wesley, 1999, Penzes et al., 2001). The S protein is a large transmembrane surface glycoprotein that induces virus-...
The spike protein of SARS-CoV—a target for vaccine and therapeutic development. Nat Rev Microbiol. 2009;7:226–36. Article CAS Google Scholar Yu, Y., Xu, J., Li, Y., Hu, Y., & Li, B. Breast milk‐fed infant of COVID‐19 pneumonia mother: A case report. Research Square, ...
本试剂盒中使用的2019-nCoV Mpro/3CLpro是碧云天采用自主研发的PerfectProtein™蛋白表达技术平台纯化而来,使表达的重组2019-nCoV Mpro/3CLpro蛋白没有任何额外的标签,没有任何一个额外的氨基酸,确保与2019-nCoV病毒的Mpro/3CLpro氨基酸序列完全一致。采用本试剂盒用于新型冠状病毒抑制剂的筛选,可确保筛选获得的...
In contrast, compact M protein is associated with flexibility and low spike density. Analysis of several types of virus-like particles and virions revealed that S protein, N protein and genomic RNA each help to regulate virion size and variation, presumably through interactions with M. These ...