To investigate the radio- sensitive effect of SSd and its possible mechanism, we combined SSd with radiation therapy to treat hepatocarcinoma cell SMMC-7721 under oxia and hypoxia.Bao-Feng WangZhi-Jun DaiXi-Jing WangMing-Hua BaiShuai Lin
Definition Is a point in the G2 phase of the cell cycle where cells become arrested in response to DNA damage . The G 2 /M checkpoint is regulated by proteins that modify or sequester the components of the Cyclin B /Cdc2 kinase complex, the principal enzymatic activity responsible for the...
The spindle checkpoint or mitotic checkpoint is a cell cycle checkpoint that delays the segregation until all chromosomes are correctly attached to the mitotic spindle. From: Advances in Protein Chemistry and Structural Biology, 2023 About this pageSet alert ...
In subject area: Neuroscience The M Phase Cell Cycle Checkpoint is a regulatory mechanism that prevents cells with damaged DNA, originating from earlier phases, from entering mitosis by inhibiting the CDK1-cyclin B complex. It ensures proper chromosome segregation during cell division. ...
The G2/M cycle checkpoint prevents cells with genomic DNA damage from entering mitosis (M phase). The main safeguards conferred by this checkpoint is to ensure that DNA is free of major lesions or replication errors, and there are enough organelles, metabolites, and other cellular cargo in ...
The DNA damage checkpoint halts cell cycle progression in G2 in response to genotoxic insults. Central to the execution of cell cycle arrest is the checkpoint-induced stabilization of securin-separase complex (yeast Pds1-Esp1). The check... YCQ Xia,CD Boy,I Shi,... - 《Nucleic Acids Rese...
Key words:G2/M cell cyclecheckpoints;cyclinB;Cdc2;Cdc25 细胞周期指连续分裂细胞从一次有丝分裂结束到下一次有丝分裂结束所经历的整个过程,通常分为Gl期、S期、G2期和M期,在这四个时相中均发生特定的生物化学反应。正常细胞中,在G1/S和G2/M期的转换以及S期的进行都是受到严密调控的。为保证细胞的遗传物质...
TNF-α Impairs the S-G2/M Cell Cycle Checkpoint and Cyclobutane Pyrimidine Dimer Repair in Premalignant Skin Cells: Role of the PI3K–Akt Pathway Tumor necrosis factor-alpha (TNF-alpha) is induced by UVB radiation and has been implicated in the early stages of skin carcinogenesis. Here, we ...
Molecules 2012, 17, 3736-3750; doi:10.3390/molecules17043736 Article OPEN ACCESS molecules ISSN 1420-3049 www.mdpi.com/journal/molecules Xanthatin Induces Cell Cycle Arrest at G2/M Checkpoint and Apoptosis via Disrupting NF-κB Pathway in A549 Non-Small-Cell Lung Cancer Cells Lei Zhang 1,2,...
As a result, the cell cycle is a tightly controlled process in which a number of checkpoints decide whether to allow a division to continue or stop it. The beginning of some cell cycle processes, including DNA replication, spindle formation, nuclear membrane breakdown, and chromosomal segregation...