Regulated cell death is intrinsically associated with inflammatory liver disease and is pivotal in governing outcomes of metabolic liver disease. Different types of cell death may coexist as metabolic liver disease progresses to inflammation, fibrosis, and ultimately cirrhosis. In addition to apoptosis, ...
Regulated cell death is intrinsically associated with inflammatory liver disease and is pivotal in governing outcomes of metabolic liver disease. Different types of cell death may coexist as metabolic liver disease progresses to inflammation, fibrosis, and ultimately cirrhosis. In addition to apoptosis, ...
Cell death is an essential mechanism for maintaininghomeostasisin multicellular organisms. Apoptosis, a form ofprogrammed cell death, involves the fragmentation of cellular contents engulfed byphagocytic cells. Apoptosis is considered a “quiet death” because of the containment and clearance of apoptotic ...
1a). Monitoring cell proliferation showed that most of the expansion occurred after the third day (Fig. 1b, c), and the proportion of Vγ9Vδ2 T cells in the cultures increased dramatically around the fourth day (Fig. 1d and Supplementary Fig. 1b) with only a minor residual fraction ...
contact site, called the immune synapse, causing target cell death through apoptosis28,29. Alternative apoptosis-inducing mechanisms have been described, such as the engagement of death receptors (FAS and TRAIL) with their ligands30. In γδ T cells, although cytokine secretion and cytolytic ...
Lytic infection leads to extensive viral gene expression, production of new infectious virions and finally death of the infected host cell (Chang et al., 2012). A latent form of infection allows the virus to persist in a dormant form for the life of the host through its tightly restricted ...
Thus, pathologic stress-instructed growth factor signaling pathways and microenvironmental changes provoking cell growth and myocardial ischemia, respectively, employ HIF to create a metabolic constellation permissive for further tissue expansion. This metabolic constellation, when protracted, leads ultimately to...
% Cell Death In E. coli Control - 0 0 0 0 0 Tetracycline - 0.5 0 68 0 0 Tetracycline - 5.0 58 88 58 47 Streptomycin - 0.5 0 99.9 68 0 Streptomycin - 5.0 87 58 99.9 99.9 % Cell Death In S. auerus Control - 0 0 0 0 0 ...
but requires de novo RNA and protein synthesis. J. R. Ortaldo, et al., "Effects of Metabolic Inhibitors on Spontaneous and Interferon-Boosted Human Natural Killer Cell Activity," J. Immunol., 125:1839-1844 (1980). However, the molecules and mechanism involved in this enhancement have been ...
so as not to affect normal gastrointestinal flora or metabolic order. Alternatively, the lytic peptides may be inherently stabilized proteolytically resistant (due to chemical modification) to accommodate oral delivery thereof. Peptides delivered to a neoplastic locus in active lytic form may usefully ...