Lysosome-related organelles (LROs) are a group of cell-type-specific membrane compartments in metazoans that share several features, including low pH and certain luminal contents, with lysosomes. Despite sharing features with lysosomes, the LROs of higher animals are highly specialized in terms of ...
Lysosome-related organelles (LROs) are a heterogeneous group of vesicles that share various features with lysosomes, but are distinct in function, morphology, and composition. The biogenesis of LROs employs a common machinery, and genetic defects in this machinery can affect all LROs or only an...
Summary As lysosome-related organelles (LROs) are required for the physiology of the organism but not for the viability of the cell that generates them, heritable defects in the formation, composition, motility, or secretion of LROs often result in disease. This chapter describes the variety of...
which are delivered to lysosomes by the autophagosomal pathway. As damaged organelles release pro-apoptotic proteins, their removal protects from cell injury (Ravikumar et al.2010). On the other side, most lysosomes contain relatively large amounts of redox-active iron and in combination with a ...
Specialized cell types hosting lysosome-related organelles (LROs) adapt their intracellular trafficking to generate and maintain these particular organelles18. Melanosomes are LROs of epidermal and uveal melanocytes (choroid, iris and ciliary body) and of the retinal pigment epithelium (RPE). Their ...
Lysosome, a vital organelles of eukaryotic cells,1 contributes significantly toward maintaining various intracellular events such as autophagy, digestion and repair of plasma membrane, etc.2,3 Lysosomal cell membrane has well-arranged enzymes, which have potential to break down all biopolymers such as ...
Rab27A is particularly involved in regulation of transport of ''lysosome-related organelles (LROs)''6,7. LROs resemble morphologically lysosomes with electron-dense protein deposits, and contain most lysosomal proteins, and have a low luminal pH. However, they display many distinct morphological, ...
In addi- tion to its function in the maturation of lysosomes and in traf- ficking cargoes to lysosomes or lysosome-related organelles (LROs),5 the HOPS complex is involved in autophagosome-lyso- some fusion by interacting with STX17 (syntaxin 17),6,7 one component of the autophagic SNARE ...
Furthermore, LRK-1 functions within a genetic pathway consisting of GLO-1 as well the adaptor pro- tein complex 3 (AP-3) component, APB-3, which is essential for vesicular endosomal trafficking to lysosomes or lysosome-related organelles (LROs)26,27. Further genetic epistasis analyses ...
immune-system-related diseases, infectious diseases, cancer,cell differentiation, and so-calledlysosomal storage diseases[4,5]. Althoughlysosomesare present ubiquitously inmammalian cells, there are cell type-specific compartments, termed lysosome-related organelles (LROs), which are roughly similar to ly...