Involution of the mammary gland after lactation is a dramatic example of coordinated cell death. Weaning causes distension of the alveolar structures due to the accumulation of milk, which, in turn, activates STAT3 and initiates a caspase-independent but lysosome-dependent ...
Massive and prolonged LMP leads to a special form of programmed cell death, called lysosome-dependent cell death (LDCD), of which the extruding cathepsin B and cathepsin D are the main executors (reviewed in (Wang et al.2018)). These through LMP extruding proteases are thought to further pro...
Integrated analysis of single-cell and bulk RNA sequencing data reveals prognostic characteristics of lysosome-dependent cell death-related genes in osteosarcoma 2024, BMC Genomics Lysosome-Disrupting Agents in Combination with Venetoclax Increase Apoptotic Response in Primary Chronic Lymphocytic Leukemia (CLL...
Though many nanoparticles interact with cells without acute toxic responses, amino-modified polystyrene nanoparticles are known to induce cell death. We have found that by lowering their dose, cell death remains low for several days while, interestingly, cell cycle......
It could be demonstrated that GBA mutants promote α-synuclein accumulation by reduced lysosomal function in a dose- and time-dependent manner, whereby lack of glucocerebrosidase activity initially led to neuronal ubiquitinopathy and axonal spheroids.31–44 In a mouse model, downregulation of autophagy...
Pyroptosis is also dependent on the lysosome, as inducers of pyroptosis require caspase-1 to act on lysosomes and promote the organelles’ leakage for eventual cell death [54]. We propose an alternative mechanism for understanding ICD that underlines the central role of the lysosome in initiating ...
Our data thus uncovered a novel context-dependent activity of phenothiazines in SCLC and suggest that phenothiazines could be considered as a treatment regimen of this disease, however, extended cell line analyses as well as in vivo studies are needed to make such conclusion. Cell Death and ...
Autophagy is a lysosome-dependent self-renewal mechanism that degrades and recycles cellular components in eukaryotic cells to maintain the stability of the intracellular environment [33]. It has been previously demonstrated that autophagy plays a crucial role in the various stages of DFU healing, ...
Nobel In Medicine: Recycling Cell Waste As a lysosome inhibitor, CQ led to the aggregation of autophagosomes and increased LC3-II level in diosgenin-treated K562 and Ba[F.sub.3]-WT cells (Fig. Diosgenin induces ROS-dependent autophagy and cytotoxicity via mTOR signaling pathway in chronic myelo...
Additionally, Heat shock protein 70 (Hsp70), a molecular chaperone, can prevent LMP by scavenging the intra-lysosomal redox active iron, thus protecting against ROS induced LMP dependent cell death [94]. 8.2 Proteases Although the discharge of cathepsins from lysosomes into cytosol is a ...