Lysosome-dependent cell death (LCD) plays a significant role in overcoming cancer apoptosis and drug resistance. However, the relationship between LCD-associated genes (LCDGs) and glioma, including glioblastoma (GBM) and low-grade glioma (LGG), remains unclear. In this study, an LCDGs risk ...
Though many nanoparticles interact with cells without acute toxic responses, amino-modified polystyrene nanoparticles are known to induce cell death. We have found that by lowering their dose, cell death remains low for several days while, interestingly, cell cycle......
19,20 Moreover, we also observed dose-dependent effects of HA on the promotion of cell death as demonstrated by increased Annexin V+ cells and caspase-3/7 activity (Figures 1G, 1H, S1H, and S1I). We also observed a dose-dependent decrease in cell proliferation by EdU assay (Figures 1...
Massive and prolonged LMP leads to a special form of programmed cell death, called lysosome-dependent cell death (LDCD), of which the extruding cathepsin B and cathepsin D are the main executors (reviewed in (Wang et al.2018)). These through LMP extruding proteases are thought to further pro...
1F, HA significantly decreased the viability of the MM cell lines, and the inhibition effect is dose-dependent. We also show the IC50 of HA in these four cell lines (Fig. 1G). To further explore the efficacy of HA on MM, we treated CD138+ cells obtained from the bone marrow of MM ...
Additionally, Heat shock protein 70 (Hsp70), a molecular chaperone, can prevent LMP by scavenging the intra-lysosomal redox active iron, thus protecting against ROS induced LMP dependent cell death [94]. 8.2 Proteases Although the discharge of cathepsins from lysosomes into cytosol is a ...
also repressed ferroptosis by reducing basal ROS generation and blocking iron metabolism in ferroptosis-sensitive cells [34]. Pyroptosis is also dependent on the lysosome, as inducers of pyroptosis require caspase-1 to act on lysosomes and promote the organelles’ leakage for eventual cell death [54...
A dose- and time-dependent effect of oxythiamine on cell growth inhibition in non-small cell lung cancer Main Phenothiazines are a family of heterocyclic compounds whose clinical utility includes treatment of psychiatric disorders, for example, schizophrenia.1In this setting, the therapeutically relevant...
It could be demonstrated that GBA mutants promote α-synuclein accumulation by reduced lysosomal function in a dose- and time-dependent manner, whereby lack of glucocerebrosidase activity initially led to neuronal ubiquitinopathy and axonal spheroids.31–44 In a mouse model, downregulation of autophagy...
Thus, NF-κB controls not only mitochondrial-dependent apoptosis but also the lysosomal pathway of cell death. Another protein released upon LMP is cathepsin D. In fact, during the mid-1990s, cathepsin D was the first lysosomal cathepsin found to be involved in apoptosis induced by several ...