在体内,通过遗传或药理学方法降低髓磷脂中LysoPS的含量或抑制GPR34可减少多发性硬化症和中风小鼠模型的神经炎症和病理。该研究结果确定GPR34是感知脱髓鞘和中枢神经系统损伤以及促进神经炎症的关键受体,并表明它是脱髓鞘相关疾病的潜在治疗靶...
As a result, inhibition of the GPR34-PI3K-AKT-NINJ1 axis significantly decreased microglial extracellular trap formation and neovascularisation by suppressing LysoPS-induced microglial inflammatory responses, both in vitro and in vivo. This study reveals the crucial role of apoptotic ganglion cells in...