Co-culture of retinal explants with LPS + IFN-γ or IL-4 pre-treated DKO microglia significantly reduced cone photoreceptor survival. Conclusions The LysMCre - Socs3 fl/fl Cx3cr1 gfp/gfp DKO mice displayed primary microglial dysfunction and developed age-related retinal microgliopathy ...
Retinal microglia in different groups of mice. Retinal flatmounts from young (3–5 months) and aged (10–12 months) Socs3fl/fl and LysMCre-Socs3fl/fl mice were stained for IBA-1. Retinal flatmounts from Cx3cr1gfp/gfp and DKO of the same age remain unstained. All samples were ...