Structure and function of the lysine methyltransferase SETD2 in cancer: From histones to cytoskeletonSETD2 is known to be the unique histone methyltransferase responsible for the trimethylation of the lysine 36 of histone H3 thus generating H3K36me3. This epigenetic mark is critical for ...
Lysine fatty acylation was discovered over 20 years ago, and there are only a few mammalian proteins known to have this modification, including interleukin 1α and TNF-α27,31. Regulating TNF-α secretion is the only known physiological function of lysine fatty acylation. However, how lysine ...
et al. Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases. Nat Commun 4, 1982 (2013). ADS CAS PubMed Google Scholar Trempe, J.-F. et al. Structure of parkin reveals mechanisms for ubiquitin ligase activation. Science 340, 1451–1455 (2013). ...
Structure and function of carbamoylphosphate synthase. I. Transitions between two catalytically inactive forms and the active form Eur. J. Biochem., 7 (1968), pp. 119-127 CrossrefView in ScopusGoogle Scholar Hall et al., 1958 L.M. Hall, R.L. Metzenberg, P.P. Cohen Isolation and charac...
The Gram-positive bacteriumCorynebactericum glutamicum is used for the industrial production of amino acids, e.g. of L-glutamate and L-lysine. In the last
ofthethreebasicresiduescriticalforproteinstructureandfunction.Lysineresiduesin proteinscanbesubjectedtoavarietyofPTMs,includingmethylation,acetylation, biotinylation,ubiquitination,ubiquitin-likemodifications,propionylationandbutyrylation, thelasttwoofwhichwererecentlyidentifiedbyus 3,4 .Extensivestudiesinthepastfew decades...
Studies on the structure and expression of the penicillin G acylase gene - I. Cloning of the penicillin G acylase gene of E. coli ATCC 11105 The process conditions of immobilizing penicillin G acylase(PGA) by epoxy resin were studied. This experiment used the Box-Behnken experimental design and...
Histone post-translational modifications are important regulators of chromatin structure and gene expression. Lysine 2-hydroxisobutyrylation sites, discovered by MS and validated by chemical synthesis, are found in active chromatin and associated with ma
This activation leads to heightened levels of p21 and the preservation of the DNA damage response.dUpper: Structure of EZH2 with domain WDB, WD-40 binding domain; D1, domain 1; D2, domain 2; CXC, Cys-rich domain; SET, catalytic domain of EZH2. Lower: The mechanistic role of EZH2 as ...
E. et al. Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases. Nat Commun 4, 1982 (2013). 8. Trempe, J.-F. et al. Structure of parkin reveals mechanisms for ubiquitin ligase activation. Science 340, 1451–1455 (2013). 9. Chaugule, V. K. ...