The function of this domain in Elp3 orthologues is not clear but it has been implicated in DNA demethylation in zygotes (44). The first step in all reactions involving the Radical SAM domain is reduction of the iron-sulfur cluster formed by three or four key cysteine residues in the ...
The histone methylation states (e.g., Kme0 to Kme3) can be linked to unique biological activities [21] and the potential signaling mechanisms and biological pathways involved in diseases for each KMT family member have been summarized in recent reviews [20,22,23]. Therefore, this review ...