Clear cell renal cell carcinoma (ccRCC) is a common histological subtype of malignant renal neoplasm. Protein lysine lactylation (Kla) plays a crucial role in tumor metabolic reprogramming. However, little is known regarding the distribution and potentia
To investigate its lactylation transfer function, overexpression of HBO1 in HEK293T cells was performed and pan-L-Kla antibody was used to detect the level of lactylation. Meanwhile, overexpression of p300 were done as positive control. Both immunofluorescence (IF) staining and western blotting ...
Furthermore, lactylation is preferentially enriched in proteins involved in immune activation and inflammatory pathways, and d-lactylation at lysine 310 (K310) of RelA attenuates inflammatory signaling and NF-κB transcriptional activity to restore immune homeostasis. Accordingly, TTP-binding site ...
Lysine l-lactylation (Kl-la) is a novel protein posttranslational modification (PTM) driven by l-lactate. This PTM has three isomers: Kl-la, N-ε-(carboxyethyl)-lysine (Kce) and d-lactyl-lysine (Kd-la), which are often confused in the context of the Warb
Abstract Protein lactylation is a newly discovered posttranslational modification (PTM) and is involved in multiple biological processes, both in mammalian cells and rice grains. However, the function of lysine lactylation remains unexplored in wheat. In this study, we performed the first compara...
ACSF2 and lysine lactylation contribute to renal tubule injury in diabetes ACSF2和赖氨酸乳酸化在糖尿病肾小管损伤中的作用 相关领域 发病机制人体生理学赖氨酸肾损伤糖尿病肾病糖尿病生物标志物医学肾病内科学肾脏疾病疾病内分泌学肾生物生物化学氨基酸 ...
Cancer cells tend to utilize aerobic glycolysis to generate energy and metabolites; the end product of aerobic glycolysis is lactate, which promotes lysine lactylation (Kla). Kla is a newly discovered histone post-translational modification (PTM) that plays important roles in regulating gene expressio...
YiaC and CobB regulate lysine lactylation in Escherichia coli 2022, Nature Communications Show abstract The EcoCyc Database in 2021 2021, Frontiers in Microbiology Show abstract Site-specific acylation of a bacterial virulence regulator attenuates infection 2020, Nature Chemical Biology Mechanisms, detect...
Background: Lysine lactylation (Kla) is a novelposttranslational modification (PTM) identified in histone and nonhistone proteins of several eukaryotic cells that directly activates gene expression and DNA replication. However, very little is known about the scope and cellular distribution of Kla in...
Breast cancer (BC) stands as a predominant global malignancy, significantly contributing to female mortality. Recently uncovered, histone lysine lactylation (kla) has assumed a crucial role in cancer progression. However, the correlation with lncRNAs rem