Lysine lactylation (Kla) links metabolism and gene regulation and plays a key role in multiple biological processes. However, the regulatory mechanism and functional consequence of Kla remain to be explored. Her
detection of lysine delactylation activity of CobB.j,kCobB regulation PykF activity by erasing K382la in vitro. PYKF was incubated with CobB to decrease K382la (j), after delactylation, detection of the activity of PykF (k).lMeasurement growth curve ofE. coliMG1655cobB+and ΔcobBstrain...
Additionally, some discoveries of histone lactylation in tumor biology were also discussed, and some prospects for this field were put forward.doi:10.1016/j.heliyon.2024.e38426Yunhao YangNanzhi LuoZhipeng GongWenjing ZhouYin KuYaohui ChenElsevier LtdHeliyon...
Furthermore, lactylation is preferentially enriched in proteins involved in immune activation and inflammatory pathways, and d-lactylation at lysine 310 (K310) of RelA attenuates inflammatory signaling and NF-κB transcriptional activity to restore immune homeostasis. Accordingly, TTP-binding site ...
(19)HDAC2‐Mediated METTL3 Delactylation Promotes DNA Damage Repair and Chemotherapy Resistance in Triple‐Negative Breast CancerAdvanced ScienceFebruary 14, 2025Xiaoniu He, Yuanpei Li, Jian Li, Yu Li, Sijie Chen, Xia Yan, Zhangrong Xie, Jiangfeng Du, Guoan Chen, Jianbo Song,et al.Anti‐...
Abstract Protein lactylation is a newly discovered posttranslational modification (PTM) and is involved in multiple biological processes, both in mammalian cells and rice grains. However, the function of lysine lactylation remains unexplored in wheat. In this study, we performed the first compara...
With the development of mass spectrometry technology and pan-antibody enrichment strategy, a number of novel PTMs have been reported, such as succinylation, malonylation, 2-hydroxyisobutyrylation and lactylation [[11], [12], [13], [14]]. These PTMs modify the net charge, conformation and ...
ACSF2 and lysine lactylation contribute to renal tubule injury in diabetes ACSF2和赖氨酸乳酸化在糖尿病肾小管损伤中的作用 相关领域 发病机制人体生理学赖氨酸肾损伤糖尿病肾病糖尿病生物标志物医学肾病内科学肾脏疾病疾病内分泌学肾生物生物化学氨基酸 ...
Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation 巨噬细胞MCT4抑制激活修复基因并通过组蛋白H3赖氨酸18乳酸化保护动脉粥样硬化 相关领域 赖氨酸组蛋白H3组蛋白乙酰化基因细胞生物学组蛋白H2ASAP30型生物生物化学氨基酸 ...
Lysine l-lactylation (Kl-la) is a novel protein posttranslational modification (PTM) driven by l-lactate. This PTM has three isomers: Kl-la, N-ε-(carboxyethyl)-lysine (Kce) and d-lactyl-lysine (Kd-la), which are often confused in the context of the Warb