Lysine lactylation (Kla) links metabolism and gene regulation and plays a key role in multiple biological processes. However, the regulatory mechanism and functional consequence of Kla remain to be explored. Here, we report that HBO1 functions as a lysin
detection of lysine delactylation activity of CobB.j,kCobB regulation PykF activity by erasing K382la in vitro. PYKF was incubated with CobB to decrease K382la (j), after delactylation, detection of the activity of PykF (k).lMeasurement growth curve ofE. coliMG1655cobB+and ΔcobBstrain...
Background: Lysine lactylation (Kla) is a novelposttranslational modification (PTM) identified in histone and nonhistone proteins of several eukaryotic cells that directly activates gene expression and DNA replication. However, very little is known about the scope and cellular distribution of Kla in...
In eukaryotes, lactate produced during glycolysis is involved in regulating multiple metabolic processes through lysine lactylation (Kla). To explore the potential link between metabolism and Kla in prokaryotes, we investigated the distribution of Kla in the cariogenic bacterium Streptococcus mutans during...
Additionally, some discoveries of histone lactylation in tumor biology were also discussed, and some prospects for this field were put forward. 展开 关键词: Histone Post-translational modification Lactate Lysine lactylation Transcription Cancer
Specifically, by mining the public human Meltome Atlas, we found that lactylation is common on glycolytic enzymes and conserved on ALDOA. We also discovered prevalent lactylation on DHRS7 in the draft of the human tissue proteome. We partially demonstrated the functional importance of lacty...
ACSF2 and lysine lactylation contribute to renal tubule injury in diabetes ACSF2和赖氨酸乳酸化在糖尿病肾小管损伤中的作用 相关领域 发病机制人体生理学赖氨酸肾损伤糖尿病肾病糖尿病生物标志物医学肾病内科学肾脏疾病疾病内分泌学肾生物生物化学氨基酸 ...
Abstract Protein lactylation is a newly discovered posttranslational modification (PTM) and is involved in multiple biological processes, both in mammalian cells and rice grains. However, the function of lysine lactylation remains unexplored in wheat. In this study, we performed the first compara...
With the development of mass spectrometry technology and pan-antibody enrichment strategy, a number of novel PTMs have been reported, such as succinylation, malonylation, 2-hydroxyisobutyrylation and lactylation [[11], [12], [13], [14]]. These PTMs modify the net charge, conformation and ...
11,12 However, whether there are other “erasers” responsible for bulk delactylation, including both histones and non-histones, remain poorly understood. Given that sirtuins are a class of enzyme with NAD+-dependent protein lysine deacylase activities,16 we hypothesized that other sirtuins may ...