1.Uptodate: Lynch syndrome(hereditary nonpolyposis colorectal cancer): clinical manifestations and diagnosis Lynch syndrome(hereditary nonpolyposis colorectal cancer): Screening and management 2.Wikipedia -https://en.wikipedia.org/wiki/Hereditary_nonpolyposis_colorectal_cancer...
Lynch syndrome (LS) is a hereditary disorder that increases the risk of colorectal cancer (CRC) due to constitutional pathogenic variants in mismatch repair (MMR) genes. When coupled with somatic mutations in the same gene, MMR deficiency occurs. However, the mechanisms driving cancer development ...
A diagnosis of suspected Lynch syndrome (SLS) is given when a tumour displays characteristics consistent with Lynch syndrome (LS), but no germline pathogenic variant is identified. This inconclusive diagnosis results in uncertainty around appropriate can
Samuel said that while the guidance around aspirin is good news for people with Lynch syndrome, "it's important to remember that aspirin can have side effects, and this draft guidance is only for people with this condition. Anyone considering taking aspirin to reduce their risk of bowel cancer...