Lynch syndrome is the most common inherited cancer syndrome, which predisposes individuals to a number of different cancers, principally colorectal and endometrial cancer. The early diagnosis of Lynch syndrome enables colorectal surveillance, which has been shown to save lives through the detection and ...
A new database of all patients with Lynch syndrome aims to improve treatment and prevention for those at high-risk of cancer.
The Lynch Syndrome mobile app will provide Lynch Syndrome carriers with their own portable patient-held, longitudinal, personal care record. All data is patient entered and requires no integration with third-party systems. The app provides NHS-approved information, support, and guidance to Lynch Synd...
For Lynch syndrome the testing strategy was rather differ- ent from the start as pre-screening with either micro-satellite Table 1 NHS England mainstream testing criteria since June 2023 for breast and other cancers for R208 (gene panel of BRCA1, BRCA2, PALB2, CHEK2, ATM, RAD51C...
Lynch Syndrome (LS) is an autosomal dominant disease conferring a high risk of colorectal cancer due to germline heterozygous mutations in a DNA mismatch repair (MMR) gene. Although cancers in LS patients show elevated somatic mutation burdens, informati
Lynch Syndrome SOC: Standard of Care MMR: Mismatch Repair EPCAM: Epithelial cell adhesion molecule NHS : National Health Service REC: Research Ethics Committee HRA: Health Research Authority SP: Study Participants LoD: Limit of Detection f-Hb: Faecal Haemoglobin rRNA: Ribosomal Ribonu...
Lynch syndrome cases are underidentified, and universal colorectal cancer tumor screening for Lynch syndrome (UTS) has been recommended. UTS implementation is challenging and few successful examples exist to date, and colorectal cancer patients and at-risk family members exhibit low uptake of genetic ...
Urology Centre, Guy’s and St Thomas’ NHS Foundation Trust, London, UKJohn Wiley & Sons, LtdBju InternationalPeterAcher, GeraldineKiela, KayThomas, TimothyO’Brien. (2010) TOWARDS A RATIONAL STRATEGY FOR THE SURVEILLANCE OF PATIENTS WITH LYNCH SYNDROME (HEREDITARY NON-POLYPOSIS COLON CANCER) ...
Two university teaching hospitals, Imperial College Healthcare and Oxford Radcliffe Hospitals NHS Trusts. Whether patients were screened for Lynch syndrome-and the outcome of that evaluation, if it took place-were assessed from patients' clinical records. The age, tumour location and family history ...
This work therefore contributes to the argument that, in certain male populations, Lynch Syndrome mutations are biologically implicated in men with prostate cancer. Keywords: BRCA1/2, Lynch Syndrome, Mismatch repair, MSH6 Mutation, Prostate cancer Abbreviations: PC, Prostate cancer; BRCA1 and BRCA2...