Six primary cancers in one lynch syndrome patient with chronic arsenic exposureJournal of Surgical OncologyPo-Chuan Chen MDWen-Chau Chen MDSheau-Chiou Chao MDBo-Wen Lin MDShao-Chieh Lin MDChia-Jung Chen RNJenq-Chang Lee MD
lynch syndrome Inherited genetic mutations that increase the chance of colorectal and certain other types of cancer, often before age 50. colorectal cancer Cancer that forms in the tissues of the colon (the longest part of the large intestine). Most colon cancers are adenocarcinomas (cancers that...
Mismatch repair-deficient breast cancers may be identified in Lynch syndrome mutation carriers, and have clinicopathological features in common with mismatch repair-deficient colorectal and endometrial cancers such as tumour-infiltrating lymphocytes and poor differentiation. Mismatch repair-deficient colorectal ca...
Recent studies have estimated that the lifetime risk of endometrial cancer in women with Lynch syndrome/hereditary non-polyposis colorectal cancer syndrome
Lynch Syndrome (LS) is the most common of the hereditary colorectal cancer (CRC) syndromes. It is caused by germ-line mutations in one of the four mismatch repair (MMR) genes MLHl, MSH2, MSH6 or PMS2. Mutations in one of these genes also predispose to several other types of cancer, ...
Lynch syndrome is an inherited condition that results in a higher risk of developing certain types of cancer. Up until now, the elevated risk was thought to be restricted mostly to colon and endometrial cancers. But in this new effort, the researchers found evidence that suggests it can also ...
Background The spectrum of cancers seen in a hospital based Lynch syndrome registry was examined to compare the incidence of colorectal versus extracolonic cancers by sex, race, mismatch repair (MMR) gene mutation, age at diagnosis and index cancer. We also examined rare extracolonic cancers that...
Lynch Syndrome (LS) is an autosomal dominant disease conferring a high risk of colorectal cancer due to germline heterozygous mutations in a DNA mismatch repair (MMR) gene. Although cancers in LS patients show elevated somatic mutation burdens, informati
Do the risks of Lynch syndrome-related cancers depend on the parent of origin of the mutation?Parent-of-origin effectIndividuals who carry pathogenic ... SD Gemechu,CMV Vliet,AK Win,... - 《Familial Cancer》 被引量: 0发表: 2020年 The imprinted gene and parent-of-origin effect database ...
International guidelines recommend universal screening for Lynch syndrome (LS) through somatic DNA mismatch repair deficiency (dMMR) testing in all colorectal cancers (CRCs). However, LS remains largely underdiagnosed. Mainstreaming LS diagnosis through oncologist-driven genetic testing could increase detectio...