Lyn/Syk信号通路目的探讨茯苓酸对支气管哮喘大鼠气道炎症及酪氨酸蛋白激酶(Lyn)/脾酪氨酸激酶(Syk)信号通路的影响及其机制.方法建立支气管哮喘大鼠模型,将大鼠分为对照组,哮喘组,Lyn抑制剂PP2组,茯苓酸5 mg/kg组及茯苓酸10 mg/kg组,观察大鼠肺组织病理学变化,并进行炎症评分.ELISA法检测支气管肺泡灌洗液(BALF)...
TheEBVlatentmembrane protein2A (LMP2A) has been implicated in the modulation of BCR signaling through its interactions with the downstreamprotein tyrosine kinases Syk, Lyn, and Btk. In this way, LMP2A alters B cell development and enhances B cell survival[31]. Targeting Btk therefore has potenti...
Brunati AM, Deana R, Folda A, Massimino ML, Marin O, Ledro S, Pinna LA, Donella-Deana A: Thrombin-induced tyrosine phosphorylation of HS1 in human platelets is sequentially catalyzed by Syk and Lyn tyrosine kinases and associated with the cellular migration of the protein. J Biol Chem. 20...
SYK and LYN mediate B-cell receptor-independent calcium-induced apoptosis in DT-40 lymphoma B-cells[J].Leukemia and Lymphoma,2002,(11):2165-2170.doi:10.1080/1042819021000032935.Zhu D. M. , Tibbles H. E. , Vassilev A. O. and Uckun F. M. ( 2002 ) SYK and LYN mediate B-cell ...
SYK and LYN mediate B-cell receptor-independent calcium-induced apoptosis in DT-40 lymphoma B-cells[J].Leukemia and Lymphoma,2002,(11):2165-2170.doi:10.1080/1042819021000032935.SYK and LYN mediate B-cell receptor-independent calcium-induced apoptosis in DT-40 lymphoma B-cells. Zhu D,Tibbles H...
Proteins were precipitated with GST fusion protein containing tandem Syk SH2 domain (GST-Syk-SH2) and separated by 15% SDS-PAGE. Tyrosine-phosphorylated FcR γ-chain was detected by blotting with:A, anti-phosphotyrosine antibody, or B, anti-FcR γ-chain. Samples were also analyzed for ...
Recent data indicate that phagocytosis mediated by FcgammaRs is controlled by the Src and Syk families of protein tyrosine kinases. In this study, we demonstrate a sequential involvement of Lyn and Syk in the phagocytosis of IgG-coated particles. The particles isolated at the stage of their bind...
ras信号通路及上游蛋白活化形式的蛋白，其磷酸化位点如何得知，主要是这四种ras、Lyn、Syk、LAT活化形式的...
The tyrosine kinases c-Fgr, Fyn, C-terminal Src kinase and p72 syk as well as the Ser/Thr-specific CAMP-dependent protein kinase and protein kinases CK1 and CK2 do not phosphorylate p57. C-terminal Src kinase, which acts to down-regulate the Src-like protein-tyrosine kinases, almost ...
因为war3才玩的d..syk的三冠王的梦化为了泡影,真心可惜啊。。。想不到2楼会被你抢到我最近火枪,敌法各种超神。。。要不来一局?要不来一局?那你还在贴吧干什么。。。