Population-based information about cancer occurrence and survival are required to inform clinical practice and research; but for most lymphomas data are lacking. Set within a socio-demographically representative UK population of nearly 4 million, lymphom
We assessed stage-specific trends in primary therapy and relative survival among adult follicular lymphoma (FL) patients diagnosed in the Netherlands between 1989–2016 (N = 12,372; median age, 62 years; and 21% stage I disease). Patients were stratified by disease stage and subsequently ...
Prolonged survival in the absence of disease-recurrence in advanced-stage follicular lymphoma following chemo-immunotherapy: 13-year update of the prospective, multicenter randomized GITMO-IIL trial 来自 Semantic Scholar 喜欢 0 阅读量: 23 摘要: A prospective trial conducted in the period 2000-2005 ...
Secondary endpoints were safety, progression free survival, duration of response and overall survival. Results Eighty pts were enrolled from 16 LYSA centres between December 2010 and January 2012. Median age was 57 y (range 29-71); 50% were male; 92% Ann Arbor stage III-IV; 28% B ...
although rare patients with limited-stage disease might be curable with radiotherapy. FL has a tendency to transform to a more aggressive lymphoma over time, most often large B-cell lymphoma (LBCL) at a rate of 3% per year. However, transformation to other entities can occur rarely, such as...
Controls were selected from the same area with 3:1 frequency matching by race, sex, vital status and age (± 2 years) by two-stage random-digit dialing, Medicare, or state mortality files. Response rates were 91.0% for cases and 87.2% for controls. Proxy respondents were used for ...
Splenic marginal zone lymphomahas an indolent clinical course with an overall 5-year survival rate of 65% to 78%, but cures are rare. Therefore asymptomatic patients can be followed without treatment. Symptomatic splenomegaly associated with varying degrees of anemia, thrombocytopenia, and neutropenia ...
Understanding AITL pathology requires defining stage(s) of Tfh development and activity that differ between physiologic and neoplastic Tfh cells (see Figs. 2, 3). Fig. 3: Schematic model of AITL generation. In the bone marrow (BM), somatic mutations in TET2 (or TET2 plus DNMT3A; marked as...
Improvement of overall survival in advanced stage mantle cell lymphoma. J Clin Oncol. 2009;27:511–8. Article PubMed Google Scholar Habermann TM, Lossos IS, Justice G, Vose JM, Wiernik PH, McBride K, et al. Lenalidomide oral monotherapy produces a high response rate in patients with ...
survival signs as a result of increased ROS production and decreased energy supply. ROS levels in the lymph gland (Fig.2A) (***P < 0.001) and the brain (Fig.2B) significantly decreased upon VK2 treatment (***P < 0.001). Mitochondrial defects associated with theheixmutation could...