1.A small, protective sac in the body. In most vertebrate animals, fertilized eggs develop in follicles located in the ovaries. In mammals, hair develops and grows from follicles in the skin. 2.A dry fruit that has a single chamber and splits open along only one seam to release its see...
It represents colonization of mantle zones of lymphoid follicles by B cells carrying an IG::CCND1 fusion leading to cyclin D1 overexpression [110]. The IGH::CCND1 fusion associated with t(11;14)(q13;q32) is the genetic hallmark of mantle cell lymphoma (MCL), present in ≥95% of cases...
CASPubMedGoogle Scholar Wang T, Lasota J, Hanau CA, Miettinen M. Bcl-2 oncoprotein is widespread in lymphoid tissue and lymphomas but its differential expression in benign versus malignant follicles and monocytoid B-cell proliferations is of diagnostic value. APMIS. 1995;103:655–62. CASPubMed...
The cortex contains large numbers of resting B cells, FDCs and macrophages arranged in lymphoid follicles, while the paracortex is home to many loosely scattered T cells and DCs. The medulla becomes well stocked with antibody-secreting plasma cells during an adaptive response. Sign in to ...
The basic structure comprises the cortex, with primary and secondary follicles (B-lymphocyte areas) and paracortex (T-cell area) and the medulla with medullary cords. Afferent lymphatics enter the node at the capsule and drain through the cortex around the follicles into medullary sinusoids. The...
The expanding malignant B-cell clone grows in follicles with particular apposition to follicular dendritic cells and heavy infiltration with CD4+ T cells. Interaction with T cells can induce the proliferation of follicular lymphoma cells. This tumor eventually evolves into a diffuse large-cell lymphoma...
solitary or multiple small benign cutaneous erythematous nodules, occurring mainly on the head and neck in young adults, characterized by dermal proliferation of blood vessels with vacuolated histiocytoid endothelial cells and with a varied infiltrate of eosinophils, lymphocytes which may form follicles,...
et al. A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature 406, 309–314 (2000). Article CAS PubMed Google Scholar Cao, X. et al. Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain. Immunity 2, 223–238 (1995). ...
It can be distinguished by the polymorphic nature of the infiltrate, the absence of significant cytologic atypia, and the presence of reactive follicles within the lesion, and by use of immunohistochemical or molecular analysis[1]. Among primary intestinal lymphomas, mantle cell lymphoma is most ...
The combined in vitro and in vivo culture system described earlier using nude mice as the hosts can also be employed to study thymic stroma as well as well-organized, highly differentiated cells of many other lineages, including gut epithelia, skin with hair follicles, bone, muscle, neurons, ...