Based on the celltype.l2 annotated by Azimuth (Supple- mentary Fig. 1b, c), we classified immune cells into four categories: T-cells (T-cell, 62,489 cells), B cells (B-cell, 14,097 cells), dendritic cells (DC,
Within tissues, ILCs have critical functions in maintaining tissue balance and responding to local inflammation and injuries4,5. ILCs are found throughout the body and can be classified into three main groups based on their surface marker expression, cytokine secretion profiles, and transcription ...
IFN-γ is the most potent stimulator for monocytes/macrophages. Excessive release of this cytokine will undoubtedly lead to monocyte/macrophage activation with concomitant production of pro-inflammatory mediators, including IL-6. Such an acute phase response in UA patients could be regarded as a ...
Also, we identified a previously unrecognized population of CD56+ monocytes (CD3-CD14+CD56+) in both the normal control subjects and the MS patients which would have been misclassified as NK cells using one or two antibody cytometry employed in previous studies....
Are they part of the innate immune system or the adaptive immune system? What are the functions of antigen-presenting cells? Explain the function and characteristics of neutrophils, eosinophils, basophils, monocytes, and lymphocytes? If a person is missing cytotoxic T cells what function will be ...
MRPs and Lkn-1 can be classified as C6 β-chemokines because they include six conserved cysteines, whereas only four cysteines are aligned in other β-chemokines. These structural features may suggest that C6 β-chemokines constitute a subgroup of β-chemokines which are associated with a ...
TIM3, the member of the TIM family of immunomodulatory proteins encoded by HAVCR2, is mainly expressed in CD8+T lymphocytes, CD4+T lymphocytes, NK cells, and monocytes [16]. In many tumors such as melanoma [17] and gastric cancer [18], the increase of TIM3 is associated with poor prog...
Here, we present three types of regulatory B cell phenotypes. Firstly, B10 cells are a subset of Breg cells capable of producing IL-10 and represent a small fraction of the CD24hiCD27+subset. When monocytes are co-cultured with activated B10 cells, tumor necrosis factor-alpha (TNF-α) pr...
(C) Fifty GBM patients were classified into two major groups (red and black clusters) by unsupervised hierarchical clustering according to the expression pattern of the Constant_imm_genes. The expression levels of these genes are illustrated as a color spectrum, with red, white and blue ...
IL-28RA is not expressed by human primary monocytes and monocyte-derived DCs, but it is expressed by monocyte-derived macrophages (MDMs) rendering them susceptible to IFN-λ11 On the whole, interferons (IFNs) type I, II, and III are essential components of the immune system’s antiviral ...