MiR-34a inhibits lymphatic metastasis potential of mouse hepatoma cells. Mol Cell Biochem. 2011; 354(1-2):275- 282.Guo Y, Li S, Qu J, Wang S, Dang Y, Fan J, Yu S, Zhang J. MiR- 34a inhibits lymphatic metastasis potential of mouse hepatoma cells. Mol Cell Biochem 2011; 354: 275...
Lymphatic metastasis, Mouse models, Breast CancerBreast cancer is the most commonly diagnosed cancer in women and the second most common cause of cancer-related deaths in the United States. Although early detection has significantly decreased breast cancer mortality, patients diagnosed with distant ...
In order to obtain lymphogenous metastasis-associated genes, we compared the transcriptional profiles of mouse hepatocarcinoma cell lines Hca-F with highly lymphatic metastasis potential and Hca-P with low lymphatic metastasis potential.Total RNA was isolated from Hca-F and Hca-P cells and synthesized...
PAI-1 could serve as an effective prognostic biomarker and therapeutic target for CSCC metastasis.Introduction Cancer progression has been considered a consequence of the evolving crosstalk between different cell types within the tumour microenvironment (TME) [1, 2]. The remodelling of regional ...
(here as two regions, T_R1 and T_R2 in Patient_8) collectively reflect its clonal composition, these regions should be taken as a whole rather than separately for subsequent metastasis route analysis. For instance, a mutation cluster that is clonal in T_R1 yet subclonal or absent in T_...
3 pathway, further activating endothelial NOS (eNOS) and inducing nitric oxide (NO·) production (Fig.2C). The latter has been associated with the induction of LEC proliferation; interestingly, a positive correlation between tumor NOS expression and lymphatic metastasis has been described165,166,...
A mouse model of lymphatic metastasis of tumor is then established and the lymphatic metastasis is successfully imaged and tracked optoacoustically. The imaging results were verified using multiple biochemical assays. Moreover, 3D MSOT renderings are obtained for precisely locating and tracking the ...
P<0.05).Transwell assays revealed that IGF-1 increased the migration and invasion of CRC cells.In vivo mouse studies showed that IGF-1 also increased LVD in LoVo cell xenografts.CONCLUSION:IGF-1/IGF-1R signaling induces tumorassociated lymphangiogenesis and contributes to lymphatic metastasis of CRC...
mouse models in other tumors with metastases [11,129]. Overexpression of VEGF-C in tumor cells encouraged intra-lymphatic spread of metastases. In clinical studies, we have found axillary lymph nodes being a rare site of LNM had a higher incidence of metastasis in BRAF mutated patients with ...
(type 1) T-cell responses [15] and natural killer (NK) cell activity [16]. Similarly to CHI3L1, CHI3L3—a mouse CLP member with no human orthologue—was identified as a common marker and driver for immunosuppressive M2 TAM polarization in the TME [17,18]. Collectively, given its ...