Any of a class of white blood cells of the vertebrate immune system, including the B cells, T cells, and natural killer cells, that in mammals derive from a common progenitor in the bone marrow and are found chiefly in lymph, lymphoid tissues, and blood. ...
Indeed, lymph nodes are interposed in the path of the lymph vessels to act as filters for the elimination of bacteria and other foreign substances. Morphologically and functionally, the parenchyma is divided into three distinct zones: the cortex, paracortex and medulla. The cortex is made up of...
Dendritic cells are formed in the bone marrow and migrate to various tissues, where they are named interstitial dendritic cells or given various tissue-specific names such as Langerhans cells of the skin. DCs in peripheral tissues assimilate local antigens and then travel in lymph to the ...
Labeled large mononuclear cells, including large lymphoid cells, monocytes and large blast cells, were confined almost exclusively to the cortex. A small number of labeled plasma cells was observed in the medullary cords. It is concluded that newly-formed bone marrow lymphocytes migrate continuously ...
Innate lymphoid cells (ILCs) are largely tissue-resident, mostly described within the mucosal tissues. However, their presence and functions in the human draining lymph nodes (LNs) are unknown. Our study unravels the tissue-specific transcriptional profi
inner (medial) wall formed by the chest (thorax). front (anterior) wall made up by the pectoralis major muscle. back (posterior) wall made up by the subscapularis, teres major and latissimus dorsi muscle There are five groups of lymph nodes in the axilla associated with each area – the...
Cancer is a complex and heterogeneous disease that has been ceaselessly bringing up impenetrable challenges to the public health of human kinds. Though for decades we see countless advances in the field of cancer treatment, such as surgery, radiation therapy and chemotherapy, cancer remains a leading...
Lymph node metastasis (LNM), a common metastatic gastric-cancer (GC) route, is closely related to poor prognosis in GC patients. Bone marrow-derived mesenchymal stem cells (BM-MSCs) preferentially engraft at metastatic lesions. Whether BM-MSCs are specifically reprogrammed by LNM-derived GC cells...
Lymph fluid enters the lymph node via the afferent lymphatics, which connect to a network of sinuses running underneath the capsule. Lymph travels through the cortex to the medulla and leaves via the efferent lymphatics in the hilum. The lymph node parenchyma is composed of a cortex, which ...
Lymphangiogenesis, the formation of new lymphatic vessels, occurs in primary tumors and in draining lymph nodes leading to pre-metastatic niche formation. Reliable in vivo models are becoming instrumental for investigating alterations occurring in lymph