(1986) B-Ly 1 cells: immortal Ly- 1+ B lymphocyte cell lines spontaneously arising in murine splenic cultures. Immunol. Rev. 23, 5.Braun J, Citri Y, Baltimore D, et al. B-Ly1 cells:Immortal Ly-1 + B lymphocyte cell lines spontaneously arising in murine splenic cultures [ J ]. lmm...
Goodell说,“这表明这些早期T细胞系祖细胞的产生确实依赖Lyl-1。我们认为Lyl-1控制着一种允许这些至为重要的祖细胞存活和增殖的程序。” 这一发现可能也有助于人们理解一种类型的白血病,即急性T淋巴细胞白血病(T-cell acute lymphoblastic leukemia)。研究人员发现,就这种类型的疾病而言,癌细胞类似于这些早期T细胞系祖细...
Cell-free extracts of various bacteria were active in catalyzing the synthesis of pimelyl-CoA from pimelic acid and CoA. The pimelyl-CoA formed was determined in a reaction coupled with the 7-keto-8-aminopelargonic acid (KAPA) synthetase system, which is required to convert pimely-CoA to ...
- 《Cell Stem Cell》 被引量: 207发表: 2009年 Overexpression of a transcription factor LYL1 induces T- and B-cell lymphoma in mice LYL1, a member of the class II basic helix-loop-helix transcription factors, is aberrantly expressed in a fraction of human T-cell acute lymphoblastic leuk.....
The finding may have particular import in understanding a form of leukemia known as T-cellacute lymphoblastic leukemia. The researchers found that the forms of the disease that have the worst prognosis are those in which thecancer cellsresemble these early T lineage progenitor cells. These cells ...
Lyell Immunopharma, Inc. announced that a poster describing the first-in-human Phase 1 trial design for LYL797, Lyell’s ROR1-targeted CAR T-cell therapy enhanced with genetic and epigenetic reprogramming for the treatment of solid tumors, is being presented today at the Europ...
Lyl-1 and E2α protein can form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells. Lyl-1 is involved in a chromosomal aberration which causes a form of T cell acute lymphoblastic leukemia (T-ALL). 仅用于科研。不用于诊断过程。未经明确授权不得转售。
Lyll null mice are viable but have a diminution of immature hematopoietic progenitors and partial block of pro-B cell differentiation [2]. Early lethality of Tall null mice cannot be rescued by Lyll [3]. However, the function of hematopoietic stem cells (HSC) in Lyll;Tall double-knockout...
We identify SPI1 as a potential regulator for EHT and find that knocking down SPI1 in in-vitro-generated hemogenic endothelium (HE) results in a reduction of hematopoietic progenitor cell (HPC) numbers and a diminished colony-forming unit (CFU) differentiation ability. Through multi-omic ...
The encoded protein may play roles in blood vessel maturation and hematopoeisis. A translocation between this locus and the T cell receptor beta locus (GeneID 6957) on chromosome 7 has been associated with acute lymphoblastic leukemia.包装清单: 产品编号 产品名称 包装 L28382 LYL1 Knockout HEK...