Human LY6 gene family: potential tumor-associated antigens and biomarkers of prognosis in uterine corpus endometrial carcinoma
[6] Upadhyay, Geeta. "Emerging role of lymphocyte antigen-6 family of genes in cancer and immune cells. "Frontiers in immunology 10 (2019): 819. [7] Beliakov, I. S., T. A. Karakasheva, and N. N. Mazurenko. "Exon-intron structure of the LY6G6D gene. "Molecular biology 43 (2009...
Stem cell antigen-1 (Sca-1) is the first identified member of mouse Ly6 gene family. We discovered that Sca-1 disrupts TGF尾 signaling and enhances mammary tumorigenesis in a DMBA-induced mammary tumor model. Sca-1 gene is lost during evolution in humans. Human Ly6 genes Ly6D, LyE, ...
Sca-1 is an 18 kDa phosphatidylinositol-anchored protein that is a member of the lymphocyte antigen 6 (Ly-6) family. Sca-1 is encoded by the strain-specific Ly-6 E/A allelic gene. Its expression on multipotent hematopoietic stem cells (HSC) has been used as a marker of HSCs in mice ...
Recently, the gene for Ly-6I was characterized (11) and was found to be near the genes for both Ly-6A/E and TSA-1/Sca-2/Ly-6e on mouse chromosome 15 (12, 13). Most hemopoietic cells express one or more members of the Ly-6 superfamily, and the expression of Ly-6 proteins ...
lipophilic moiety from the protein is stronger evidence, and is presented here for members of the Ly-6 family of lymphocyte antigens: Ly-6A, C and E... JW Hammelburger,RGE Palfree,S Sirlin,... - 《Biochemical & Biophysical Research Communications》 被引量: 61发表: 1987年 Gene for hum...
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By differential display-PCR, we isolated and characterized a novel gene (RIG-E) whose expression is up-regulated by ATRA. The gene is 4.0 kb long, consisting of four exons and three introns, and is localized on human chromosome region 8q24. The deduced amino acid sequence predicts a cell...
The gene Gm191, which is located on chromosome 9, encodes SSLP-1. By Northern blotting with 21 different mouse tissues, we found that Sslp-1 mRNA was predominantly expressed in the seminal vesicle. Immunohistochemistry revealed SSLP-1 protein in the luminal fluid and mucosal epithelium of the ...
We analyzed the influence of the Aβ hyperexpression in the cerebellum of 2xTg-AD mice on Klf4 expression using real-time PCR and revealed, similarly to Lynx1 and Slurp1, significant down-regulation of this gene expression (Figure 5a). Western blotting confirmed the down-regulation of KLF4 ...