The LxxLL motif: a multifunctional binding sequence in transcriptional regulation. Trends Biochem. Sci. 30 : 66-69.Plevin MJ, Mills MM, Ikura M. The LxxLL motif: a multifunctional binding sequence in transcriptional regulation . Trends Biochem Sci 2005; 30 : 66–9....
In general, the LxxLL motif adopts a short a-helical structure and docks into a hydrophobic co-activator-binding pocket sur- rounded by helices H3, H4, H5 and H12 of the LBD (17). Mutational analyses of the co-activators NR boxes have also uncovered a receptor specific code of inter-...
Several recently reported 3D structures of protein–LxxLL motif complexes and an intriguing novel interaction implicated in leukaemia have further highlighted the diversity and regulatory importance of this seemingly simple motif.关键词: Animals Humans Transcription Factors Repressor Proteins Trans-Activators ...
Evidence suggested that the sequences flanking the LXXLL motif in a number of coactivators determine receptor selectivity. We performed mutagenesis studies at residues adjacent to the TRBP LXXLL motif and identified S884 of TRBP at the -3 position of the LXXLL motif as a key residue for receptor...
An LXXLL motif in nuclear receptor corepressor mediates ligand-induced repression of the thyroid stimulating hormone-beta gene. J Steroid Biochem Mol Biol. 2005; 97 :322–327. doi: 10.1016/j.jsbmb.2005.06.031. [ Cross Ref ]Loinder K, Soderstrom M. An LXXLL motif in nuclear receptor core...
The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity. J. Clin. Invest. 116:2473-2483.Nakae J, Cao Y, Daitoku H, et al. The LXXLL motif of murine forkhead transcription factor FOXO1 mediates Sirt1-dependent transcriptional activity. J ...
The coactivator LXXLL nuclear receptor recognition motif. J Pept Res. 2004;63:207-212.Savkur RS,Burris TP.The coactivator LXXLL nuclear receptor recognition motif. Journal of Peptide Research . 2004Savkur, R. S. and Burris, T. P. (2004) The coactivator LXXLL nuclear receptor recognition ...
However, a close inspection of the electron density map indicates that the bound LXXLL motif is not a selected one but an averaged structure of more than one LXXLL motif. Further biochemical and functional studies show that the individual LXXLL motifs can bind but drive only minimal ...
The signature motif, LLL, which is responsible for binding of several coactivators to nuclear receptors, is not required for RIP140 binding to AhR. These results demonstrate that the AhR recruits coactivators that are capable of enhancing transcription and, thus, the AhR may compete with steroid ...
This timely translocation depends on two tandem LXXLL motifs in the N聽terminus of Mps1, and mutations in either motif abolish Mps1 nuclear accumulation. Furthermore, we found that phosphorylation of Mps1 Ser80 (which is located between the two LXXLL motifs) also plays a role in regulating ...