s conflict test with MED of 10 mg/kg. Lurasidone (3 mg/kg, 2 weeks) significantly suppresses hyperactivity behavior in olfactory bulbectomy model rats. Lurasidone (700 mg/kg–1000 mg/kg) slightly prolongs the duration of loss of righting reflexes elicited by hexobarbital (anesthesia) in mice...
While there is some open-label extension data for SGAs in these therapeutic areas, there remains a lack of long-term trials overall to provide long-term safety and efficacy data. In clinical practice, once an SGA is started for treatment of these conditions, the duration of use often extends...
the LATUDA dose should be reduced to half of the original dose level. Similarly, if a moderate CYP3A4 inhibitor is being prescribed and LATUDA is added to the therapy, the recommended starting dose of LATUDA is 20
Lurasidone(700mg/kg - 1000mg/kg) dose-dependent slightly prolonged the duration of cyclohexenobarbital (anesthesia) -induced righting reflex loss in mice. Lurasidone(30mg/kg,p.o.) significantly dose-dependent reversed the attenuation of MK-801-induced passive response avoidance in rats. Lurasidone...
Residence time (tR) [the inverse of dissociation rate constant (koff)] of drugs on targets is a critical parameter that may predict in vivo efficacy as it measures the duration of the drug-receptor interacting complex. Serotonin 5-HT7 receptors are G protein-coupled receptors expressed in centr...
Results: Fifty-six trials (n = 21691) in schizophrenia (N = 49, n= 19 299) or bipolar disorder (N = 7, n = 2392) were identified (asenapine: N = 9, iloperidone: N=11, lurasidone: N = 8, paliperidone: N = 28). Most of the trials (64.3%) were of ≤12 weeks’ duration....
Trials were 4-10 weeks duration, and most involved a flexible-dose design. The aripiprazole trial had a body weight consideration for dosing (above or below 50kg), with a mean dose of 13.61±5.37mg/day (range 5-20mg/day). The quetiapine trial was also flexible dose, with a mean of 294...
Common side effects of Latuda include: drowsiness, dizziness, nausea, diarrhea, stomach pain, loss of appetite, shaking, muscle stiffness, weight gain, mask-like facial expression, inability to keep still, restlessness, agitation, blurred vision, ...
Common side effects of Latuda include: drowsiness, dizziness, nausea, diarrhea, stomach pain, loss of appetite, shaking, muscle stiffness, weight gain, mask-like facial expression, inability to keep still, restlessness, agitation, blurred vision, ...
Common side effects of Latuda include: drowsiness, dizziness, nausea, diarrhea, stomach pain, loss of appetite, shaking, muscle stiffness, weight gain, mask-like facial expression, inability to keep still, restlessness, agitation, blurred vision, ...