Here, we sought to understand how the lupus skin environment contributes to LC ADAM17 dysfunction and, in the process, differentiate between effects on LC ADAM17 sheddase function, LC ADAM17 expression, and LC numbers. We show through transcriptomic analysis a shared IFN-rich enviro...
Hydroxychloroquine (Plaquenil).This medicine helps control mild lupus-related problems, such as skin and joint disease. It can also prevent symptom flares. Because of potential side effects, you should have regular eye checkups if taking antimalarial drugs for lupus. ...
Aside from the visible effects of systemic lupus, the disease may also inflame and/or damage the connective tissue in the joints, muscles, and skin, along with the membranes surrounding or within thelungs,heart,kidneys, andbrain. SLE can also causekidney disease.Braininvolvement is rare, but f...
Photoprotection by thalidomide in patients with chronic cutaneous and systemic lupus erythematosus: discordant effects on minimal erythema dose and sunburn... Summary Background Thalidomide is an anti-inflammatory and immunomodulatory agent with proven efficacy in several refractory inflammatory skin conditi...
We investigated the effects of cyclosporin A (CyA) on the development of lupus dermatoses in autoimmune-prone MRL/Mp-lpr/lpr (MRL/lpr) mice. The MRL/lpr mouse is an animal model for the spontaneous development of skin lesions similar to those of human lupus erythematosus (LE). Virgin ...
The effects of FK506, a new immunosuppressive agent, on the development of lupus dermatoses were investigated in the autoimmune-prone MRL/Mp-lpr/lpr (MRL/lpr) mouse, which is an animal model for the spontaneous development of skin lesions similar to those of human lupus erythematosus (LE)....
Reiss, A. B. Effects of inflammation on cholesterol metabolism: Impact on systemic lupus erythematosus.Curr. Rheumatol. Rep.11, 255–260 (2009). PubMed Feichtinger, R. G., Sperl, W., Bauer, J. W. & Kofler, B. Mitochondrial dysfunction: A neglected component of skin diseases., 607–614...
? 2024 Elsevier LtdSystemic lupus erythematosus (SLE) is a multisystemic autoimmune disease characterised by the presence of autoantibodies towards nuclear antigens, immune complex deposition, and chronic inflammation at classic target organs such as skin, joints, and kidneys. Despite substantial advances...
LUPKYNIS® (voclosporin) can cause serious side effects, including: Increased risk of cancer. People who take LUPKYNIS have an increased risk of getting some kinds of cancer, including skin and lymph gland cancer (lymphoma). Limit and avoid exposure to sunlight and UV light such as tanning...
OBJECTIVE: To examine the effects of corticosteroids used for concomitant disease states in patients with latent or active tuberculosis (TB). The role of c... JR Cisneros,KM Murray - 《Annals of Pharmacotherapy》 被引量: 191发表: 1996年 Isoniazid prophylaxis differently modulates T-cell responses...